118604-69-6

Basic information

• Product Name: Benzenamine, 2-ethyl-N-[(1R)-2-methoxy-1-methylethyl]-6-methyl-
• CAS NO: 118604-69-6
• Molecular Formula: C13H21NO
• Molecular Weight: 207.316
• Mol File: 118604-69-6.mol
• Article Data: 45

Chemical Properties

• CAS DataBase Reference: Benzenamine, 2-ethyl-N-[(1R)-2-methoxy-1-methylethyl]-6-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-ethyl-N-[(1R)-2-methoxy-1-methylethyl]-6-methyl-(118604-69-6)
• EPA Substance Registry System: Benzenamine, 2-ethyl-N-[(1R)-2-methoxy-1-methylethyl]-6-methyl-(118604-69-6)

Safety Data

• Hazardous Substances Data: 118604-69-6(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 24549-06-2 6-ethyl-o-toluidine 
• 23652-67-7 ethyl (Z)-β-acetylaminobut-2-enoate 
• 132034-47-0 N-(2-ethyl-6-methylphenyl)-N-(1'-methoxymethyl)-ethylidene-amine 
• 5878-19-3 Methoxyacetone 
• 118604-68-5 N-(2’-methyl-6’-ethyl-phenyl)-N-1-(methoxymethyl)ethylimine 
• 85385-06-4 2,6-dimethylphenyl-1'-methyl-2'-methoxyethyl-imine 
• 22461-48-9 2-Bromo-1-methoxypropane 

Downstream Products

• 178961-20-1 (aRS,1'R)-(+)-N-(1'-Methyl-2'-methoxyethyl)-N-chloracetyl-2-ethyl-6-methylanilin 
• 87392-12-9 (S)-metolachlor 
• 343629-68-5 N-(2-ethyl-6-methylphenyl)-N-(1-methoxypropan-2-yl)benzamide 
• 126404-32-8 3-[(2-Ethyl-6-methyl-phenyl)-(2-methoxy-1-methyl-ethyl)-carbamoyl]-but-3-enoic acid methyl ester 
• 51218-45-2 2-chloro-6'-ethyl-N-(2-methoxy-1-methylethyl)acet-o-toluidide 
• 68545-14-2 N-(2-Ethyl-6-methyl-phenyl)-3-methoxy-N-(2-methoxy-1-methyl-ethyl)-propionamide 

Relevant articles and documents

More than 100,000 Turnovers with Immobilized Ir-Diphosphine Catalysts in an Enantioselective Imine Hydrogenation

A modular concept to prepare immobilized enantioselective catalysts is described, consisting of a functionalized xyliphos ligand covalently attached to a support via a linker. Immobilized xyliphos bound to silica and to polystyrene as well as soluble dime

Iridium ferrocenyl diphosphine catalyzed enantioselective reductive alkylation of a hindered aniline

The enantioselective reductive alkylation of 2-methyl-5-ethyl-aniline (MEA) with methoxyacetone - using a catalyst generated in situ from [Ir(cod)Cl]2 and (R)-(S)-PPF-P(3,5-xyl)2 - to give enriched (S)-N-(2- ethyl-6-methylphenyl)-N-(1'-methoxymethyl)-ethyl-amine is described. At 80 bar and 50 °C in the presence of iodide and methane sulfonic acid and with cyclohexane as solvent, complete conversion is reached within 14 h with a substrate to catalyst ratio of 10'000 and an ee of 76-78%. The effect of solvent and acid type were found to be important. To our knowledge, this is the first enantioselective reductive alkylation ever reported.

Compound herbicide based on dichloro quinolinic acid

The invention discloses a compound herbicide based on quinclorac, which comprises 20 - 30 parts of quinclorac. Dichloromethane 3-8 parts, synergist 10 - 20 parts, wetting agent 1.5 - 4.5 parts, dispersing agent 1-3 parts, defoaming agent 0.5 - 2.5 parts and water 50 - 70 parts. The synergist inhibits the growth of cells by hindering the synthesis of the protein, and the sprouts of monocotyledonous plants are obtained through young buds of plants. The lower endoderm of the dicotyledonous plant is absorbed and conducted upwards, the seeds and roots absorb conduction, the absorption amount is low, the conduction speed is slow, the growth of young buds and roots is inhibited.

Method for preparing chiral amine through asymmetric hydrogenation based on glucose-derived monodentate phosphite ligand

The invention discloses a method for preparing chiral amine through asymmetric hydrogenation based on a glucose-derived monodentate phosphite ligand. The method comprises the following steps: reactinga chiral glucose-derived monodentate phosphite ligand with a metal iridium precursor to prepare a complex in situ as a catalyst, and carrying out asymmetric hydrogenation on imine to prepare chiral amine. The proper catalyst dosage (by mole) is as follows: the raw material imine/catalyst (S/C) is equal to 100-500,000. The ligand disclosed by the invention is simple to prepare, the catalyst dosageis low, the operation is simple and convenient, continuous operation can be realized, the method is suitable for large-scale preparation of chiral amine, the enantiomeric excess (ee value) of the product reaches 70% or above, and the requirement of serving as a pesticide intermediate can be met. According to the method, a good result is obtained for synthesis of an s-metolachlor intermediate, andthe method has good industrial practicability.

Method for asymmetric reductive amination based on fructose-derived chiral monodentate phosphite ligand ketone

The invention discloses a method for preparing chiral amine based on asymmetric reductive amination of fructose-derived chiral monodentate phosphite ligand ketone, which comprises the following steps:reacting fructose-derived chiral monodentate phosphite ligand with a metal iridium precursor to prepare a complex in situ as a catalyst, and carrying out direct asymmetric reductive amination on ketone and amine to prepare chiral amine. The ligand disclosed by the invention is simple to prepare, the catalyst dosage is low, the operation is simple and convenient, continuous operation can be realized, the method is suitable for large-scale preparation of chiral amine, the enantiomeric excess value of the product reaches 80% or above, and the requirement of serving as a pesticide intermediate can be met. The method disclosed by the invention has a relatively good result when 2-ethyl-6-methylaniline/catalyst (S/C) is 10000 during synthesis of an s-metolachlor intermediate, the yield is 95%, the enantioselectivity is 85%, and the method has very good industrial practicability.