1186194-02-4

Basic information

• Product Name: benzyl 6-chloro-2-fluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate
• Synonyms: benzyl 6-chloro-2-fluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate
• CAS NO: 1186194-02-4
• Molecular Weight: 491.989
• Mol File: 1186194-02-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: benzyl 6-chloro-2-fluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 6-chloro-2-fluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate(1186194-02-4)
• EPA Substance Registry System: benzyl 6-chloro-2-fluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate(1186194-02-4)

Safety Data

• Hazardous Substances Data: 1186194-02-4(Hazardous Substances Data)

Upstream product

• 918523-46-3 benzyl 2-fluoro-3-amino-6-chlorobenzoate 
• 10147-36-1 n-propanesulfonyl chloride 
• 57946-56-2 2-fluoro-4-chloroaniline 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 918523-48-5 6-chloro-2-fluoro-3-(propane-1-sulfonamido)benzoic acid 
• 1269421-36-4 N-(3-amino-2-fluorophenyl)propane-1-sulfonamide 
• 1268830-76-7 N-(3-amino-4-chloro-2-fluorophenyl)propane-1-sulfonamide 
• 1269652-26-7 N-(4-chloro-3-(3-(6-chloropyrimidin-4-yl)ureido)-2-fluorophenyl)propane-1-sulfonamide 
• 1269652-23-4 N-(4-chloro-2-fluoro-3-(3-(6-(methylamino)pyrimidin-4-yl)ureido)phenyl)propane-1-sulfonamide 
• 1269652-29-0 N-(3-(3-(6-(benzylamino)pyrimidin-4-yl)ureido)-4-chloro-2-fluorophenyl)propane-1-sulfonamide 
• 1186609-66-4 6-chloro-2-fluoro-N-(3-methoxy-1-(4-methoxybenzyl)-1H-pyrazolo [3,4-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide 
• 1186609-40-4 tert-butyl 5-(6-chloro-2-fluoro-3-(propylsulfonamido)benzamido)-3-ethoxy-1H-pyrazolo[3,4-b]pyridine-1-carboxylate 
• 1186607-63-5 6-chloro-N-(3-ethoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-fluoro-3-(propylsulfonamido)benzamide 
• 1186607-42-0 6-chloro-2-fluoro-N-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide 
• 1186607-83-9 6-chloro-2-fluoro-3-(propylsulfonamido)-N-(1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide 
• 1396310-77-2 N-(4-chloro-2-fluoro-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)pyrrolidine-1-sulfonamide 
• 1396310-76-1 N-(4-chloro-2-fluoro-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)dimethylsulfamide 
• 1396310-19-2 N-(4-chloro-2-fluoro-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)propane-1-sulfonamide 

Relevant articles and documents

COMPOUNDS FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS

Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF

The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.

RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF

Compounds of Formula II are useful for inhibition of Raf kinases. Methods of using compounds of Formula II and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or tr