1186224-46-3

Basic information

• Product Name: 6-nitro-2-(3-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine
• Synonyms: 6-nitro-2-(3-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine
• CAS NO: 1186224-46-3
• Molecular Weight: 308.219
• Mol File: 1186224-46-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-nitro-2-(3-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-nitro-2-(3-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine(1186224-46-3)
• EPA Substance Registry System: 6-nitro-2-(3-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine(1186224-46-3)

Safety Data

• Hazardous Substances Data: 1186224-46-3(Hazardous Substances Data)

Upstream product

• 454-92-2 3-(trifluoromethyl)benzoic acid 
• 3537-14-2 5-nitro-pyridine-2,3-diamine 
• 3073-30-1 3,5-dinitropyridin-2-amine 

Downstream Products

• 1186224-48-5 2-(3-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridin-6-amine 

Relevant articles and documents

Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase

This Letter details the synthesis and evaluation of imidazo[4,5-b]pyridines as inhibitors of B-Raf kinase. These compounds bind in a DFG-in, αC-helix out conformation of B-Raf, which is a binding mode associated with significant kinase selectivity. Structure-activity relationship studies involved optimization of the ATP-cleft binding region of these molecules, and led to compound 23, an inhibitor with excellent enzyme/cell potency, and kinase selectivity.