1186601-41-1

Basic information

• Product Name: 2-(3-(1,3-dioxan-2-yl)phenoxy)-5-methoxybenzaldehyde
• Synonyms: 2-(3-(1,3-dioxan-2-yl)phenoxy)-5-methoxybenzaldehyde
• CAS NO: 1186601-41-1
• Molecular Weight: 314.338
• Mol File: 1186601-41-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-(1,3-dioxan-2-yl)phenoxy)-5-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(1,3-dioxan-2-yl)phenoxy)-5-methoxybenzaldehyde(1186601-41-1)
• EPA Substance Registry System: 2-(3-(1,3-dioxan-2-yl)phenoxy)-5-methoxybenzaldehyde(1186601-41-1)

Safety Data

• Hazardous Substances Data: 1186601-41-1(Hazardous Substances Data)

Upstream product

• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 24393-13-3 2'-(3-hydroxyphenyl)-[1',3']-dioxane 

Downstream Products

• 1186601-43-3 (E/Z)-methyl 4-(5-(2-(3-(1,3-dioxan-2-yl)phenoxy)-5-methoxystyryl)-2-methoxyphenoxy)benzoate 

Relevant articles and documents

Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors

A series of novel macrocyclic bisbibenzyl analogues was designed, synthesized, and evaluated for their antiproliferative activity in vitro. All of the compounds were tested in five anthropic cancer cell lines, including a multidrug-resistant phenotype. Among these novel molecules, compounds 88, 92 and 94 displayed excellent anticancer activity against Hela, k562, HCC1428, HT29, and PC-3/Doc cell lines, with average IC50 values ranging from 2.23 μM to 3.86 μM, and were more potent than the parental compound marchantin C and much more potent than the positive control Adriamycin. In addition, the mechanism of action of compound 88 was investigated by cell cycle analysis and a tubulin polymerization assay in HCC1482 cells. The binding mode of compound 88 to tubulin was also investigated utilizing a molecular docking study. In conclusion, the present study improves our understanding of the action of bisbibenzylbased tubulin polymerization inhibitors and provides a new molecular scaffold for the further development of antitumor agents that target tubulin.