118670-88-5

Basic information

• Product Name: N-(2-iodobenzyl)prop-2-en-1-amine
• Synonyms: N-(2-iodobenzyl)prop-2-en-1-amine
• CAS NO: 118670-88-5
• Molecular Weight: 273.116
• Mol File: 118670-88-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-iodobenzyl)prop-2-en-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-iodobenzyl)prop-2-en-1-amine(118670-88-5)
• EPA Substance Registry System: N-(2-iodobenzyl)prop-2-en-1-amine(118670-88-5)

Safety Data

• Hazardous Substances Data: 118670-88-5(Hazardous Substances Data)

Upstream product

• 40400-13-3 2-Iodobenzyl bromide 
• 107-11-9 1-amino-2-propene 
• 948839-28-9 C₁₀H₁₀IN 
• 26260-02-6 2-iodobenzaldehyde 

Downstream Products

• 1418218-08-2 N-allyl-N-(2-iodobenzyl)acrylamide 
• 1418218-39-9 1-(2-iodobenzyl)-1H-pyrrol-2(5H)-one 
• 1418218-12-8 N-allyl-N-(2-ethynylbenzyl)acrylamide 
• 1196-39-0 4-methylisoquinoline 

Relevant articles and documents

Catalytic substitution/cyclization sequences of: O -substituted Isocyanates: Synthesis of 1-alkoxybenzimidazolones and 1-alkoxy-3,4-dihydroquinazolin-2(1 H)-ones

O-Substituted isocyanates (O-isocyanates) have rarely been used in organic synthesis, given their tendency to undergo side reactions (e.g., trimerization). Herein, we show that masked (blocked) O-isocyanate precursors allow one-pot or cascade reaction sequences featuring base-catalyzed substitution with 2-iodoanilines and 2-iodobenzylamines followed by copper-catalyzed cyclization, to form benzimidazolones and 3,4-dihydroquinazolin-2(1H)-ones. This work shows that O-isocyanates can serve as efficient building blocks for the synthesis of hydroxylamine-containing heterocycles.