1187523-95-0

Basic information

• Product Name: 3'-(2'-iodo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl
• Synonyms: 3'-(2'-iodo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl
• CAS NO: 1187523-95-0
• Molecular Weight: 596.514
• Mol File: 1187523-95-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3'-(2'-iodo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-(2'-iodo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl(1187523-95-0)
• EPA Substance Registry System: 3'-(2'-iodo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl(1187523-95-0)

Safety Data

• Hazardous Substances Data: 1187523-95-0(Hazardous Substances Data)

Upstream product

• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 
• 154542-77-5 4'-bromomethyl-2-iodobiphenyl 

Downstream Products

• 172525-90-5 4'-[(2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-benzimidazol-1-yl)methyl]-biphenyl-2-carboxaldehyde 
• 144701-48-4 telmisatran 

Relevant articles and documents

2'-Halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists

A process for obtaining 2'-halo-4-methylbiphenyls is described, which comprises reacting 4-halotoluene with a 1,2-dihalobenzene in the presence of elemental metal such as magnesium, lithium or zinc, wherein 0 to 0.9 molar, particularly 0 to 0.2 molar excess of 4-halotoluene in regard to 1,2-dihalobenzene is used, and arised organometal intermediates are quenched by elemental halogen. In addition, the coupling of arised 2'-halo-4-methylbiphenyls with 2-(1-propyl)-4-methyl-6-(1'-methylbenzimidazole-2-il)benzimidazole to afford 3'-(2'-halo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl, which can be further converted to organometallic compound and said organometallic compound is further reacted with formic acid derivative, such as N,N-dimethylformamide, alkylformiate or carbon dioxide to obtain telmisartan, is also described. Further described is use of in line analytics for monitoring the aforementioned reactions.