1187617-88-4Relevant articles and documents
PROCESS FOR PREPARATION OF TAZAROTENE
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Page/Page column 11, (2009/10/22)
Disclosed herein is process for preparation of 6-[2-(4,4-dimethylthiochroman-6- yl)ethynyl]nicotinate known as Tazarotene of Formula (I) and its pharmaceutical acceptable salts, wherein said process comprises, reacting 4,4-dimethyl-6- acetylthiochroman with chlorinating reagent to get novel intermediate compound 6- (l,l-dichloroethyl)-4,4-dimethylthiochroman followed by converting the compound 6- (l,l-dichloroethyl)-4,4-dimethylthiochroman to get Tazarotene.