1187921-93-2 Usage
Description
1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol is a chemical compound that serves as an impurity in Carvedilol, a nonselective β-adrenergic blocker with α1-blocking activity. It is characterized by its unique molecular structure, which includes a carbazol-4-yloxy group and a chloro substituent on the propane backbone.
Uses
Used in Pharmaceutical Industry:
1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol is used as an impurity in Carvedilol, which is an antihypertensive medication. The primary application of Carvedilol is in the treatment of congestive heart failure, where it helps to manage blood pressure and improve heart function.
As an impurity, 1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol is a byproduct of the synthesis process for Carvedilol. It is important to monitor and control the levels of this impurity to ensure the safety and efficacy of the final pharmaceutical product.
Check Digit Verification of cas no
The CAS Registry Mumber 1187921-93-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,7,9,2 and 1 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1187921-93:
(9*1)+(8*1)+(7*8)+(6*7)+(5*9)+(4*2)+(3*1)+(2*9)+(1*3)=192
192 % 10 = 2
So 1187921-93-2 is a valid CAS Registry Number.
1187921-93-2Relevant articles and documents
An efficient improved synthesis of carvedilol, via 2-(2-methoxyphenoxy)ethyl 4-methylbenzenesulfonate intermediate
Tatendra Reddy,Suneel Kumar,Omprakash,Dubey
, p. 1615 - 1618 (2015/02/02)
A facile synthesis of Carvedilol via a key 2-(2-methoxyphenoxy) ethyl 4-methylbenzenesulfonate intermediate is described and this approach avoids the formation of bis side product (impurity-B) due to weak basic conditions and also operationally suitable for industrial application.
AN IMPROVED PROCESS FOR PREPARATION OF CARVEDILOL INVOLVING HALOHYDRIN DERIVATIVE
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Example 1, (2009/10/22)
The present invention relates to a cost effective and industrially viable process for th preparation of Carvedilol involving halohydrin derivative
