1189260-03-4

Basic information

• Product Name: 1-phenyl-5-(thiophen-2-yl)-1H-tetrazole
• Synonyms: 1-phenyl-5-(thiophen-2-yl)-1H-tetrazole
• CAS NO: 1189260-03-4
• Molecular Weight: 228.277
• Mol File: 1189260-03-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-phenyl-5-(thiophen-2-yl)-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-5-(thiophen-2-yl)-1H-tetrazole(1189260-03-4)
• EPA Substance Registry System: 1-phenyl-5-(thiophen-2-yl)-1H-tetrazole(1189260-03-4)

Safety Data

• Hazardous Substances Data: 1189260-03-4(Hazardous Substances Data)

Upstream product

• 527-72-0 2-thiophenylcarboxylic acid 
• 62-53-3 aniline 
• 6846-13-5 N-phenyl-2-thiophenecarboxamide 
• 14210-25-4 5-Chloro-1-phenyltetrazole 
• 193978-23-3 2-thiopheneboronic acid pinacol ester 
• 3437-95-4 2-Iodothiophene 
• 5378-52-9 phenyl-1H-tetrazole 

Relevant articles and documents

Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids

The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), DFT calculations, the Molecular electrostatic potential (MEP) and ADME were investigated.

Synthesis of 1,5-disubstituted tetrazoles via Suzuki-Miyaura cross-coupling of 5-chloro-1-phenyltetrazole

Suzuki-Miyaura coupling reactions of 5-chloro-1-phenyl-tetrazole with various functionalized arylboronic acids were investigated. In the presence of catalytic amounts of SPhos/Pd(OAc)2 or RuPhos/Pd(OAc)2, the reaction proceeded smoot