118971-03-2 Usage
Description
(S)-2-(Methoxydiphenylmethyl)pyrrolidine, also known as a diphenylprolinol methyl ether, is an organic compound with a unique molecular structure that features a pyrrolidine ring with a diphenylmethyl group and a methoxy group. (S)-2-(Methoxydiphenylmethyl)pyrrolidine is known for its catalytic properties in various chemical reactions, particularly in the field of asymmetric synthesis.
Uses
Used in Chemical Synthesis:
(S)-2-(Methoxydiphenylmethyl)pyrrolidine is used as a catalyst for the enantioselective synthesis of ketones via intermolecular asymmetric Michael addition of aldehydes to nonactivated enones. This application is significant in the production of chiral compounds, which are essential in the pharmaceutical industry for the development of drugs with specific biological activities.
Used in Pharmaceutical Industry:
(S)-2-(Methoxydiphenylmethyl)pyrrolidine is used as a catalyst for the synthesis of stereoselective chiral bipyrazolidin-3-one derivatives by dipolar cycloaddition reaction of azomethine imines with α, β-unsaturated aldehydes. These chiral derivatives are valuable in the development of new drugs with improved efficacy and selectivity.
Used in Organic Chemistry Research:
(S)-2-(Methoxydiphenylmethyl)pyrrolidine is used as a catalyst for the synthesis of enantioenriched spiro nitrogen heterocycles via asymmetric nucleophilic epoxidation of α-ylideneoxindole esters. The development of such heterocycles is crucial for the creation of novel compounds with potential applications in various fields, including pharmaceuticals and materials science.
Used in Asymmetric Synthesis of Alcohols:
(S)-2-(Methoxydiphenylmethyl)pyrrolidine is used as a catalyst for the asymmetric addition of Et2Zn to various aldehydes, leading to the formation of optically active secondary alcohols. These alcohols are important building blocks in the synthesis of complex organic molecules and have applications in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 118971-03-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,9,7 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 118971-03:
(8*1)+(7*1)+(6*8)+(5*9)+(4*7)+(3*1)+(2*0)+(1*3)=142
142 % 10 = 2
So 118971-03-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H21NO/c1-20-18(17-13-8-14-19-17,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17,19H,8,13-14H2,1H3/t17-/m0/s1
118971-03-2Relevant articles and documents
Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone
Ho, Chun-Yu,Chen, Ying-Chun,Wong, Man-Kin,Yang, Dan
, p. 898 - 906 (2007/10/03)
(Chemical Equation Presented) We have synthesized a series of chiral cyclic secondary amines having different substitution patterns and have screened them as catalysts for the asymmetric epoxidation of olefins using Oxone. The highest enantiomeric excess (61%) occurred for the epoxidation of 1-phenylcyclohexene catalyzed by a secondary amine bearing a fluorine atom at the β-position relative to the amino center. Our experimental results provide further support to the notion that the amine plays a dual role - as a phase transfer catalyst and an Oxone activator - in these epoxidation reactions. The slightly acidic reaction conditions we employed in this work obviate the need to preform ammonium salts, which are the actual catalysts that mediate the epoxidations.
