118974-46-2

Basic information

• Product Name: N-[2-(2-Hydroxyethoxy)ethyl]acetamide
• CAS NO: 118974-46-2
• Molecular Formula: C6H13NO3
• Molecular Weight: 147.174
• Mol File: 118974-46-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-[2-(2-Hydroxyethoxy)ethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(2-Hydroxyethoxy)ethyl]acetamide(118974-46-2)
• EPA Substance Registry System: N-[2-(2-Hydroxyethoxy)ethyl]acetamide(118974-46-2)

Safety Data

• Hazardous Substances Data: 118974-46-2(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 929-06-6 2-(2-Aminoethoxy)ethanol 
• 141-78-6 ethyl acetate 
• 102-76-1 triacetylglycerol 
• 75-21-8 oxirane 
• 142-26-7 2-acetylaminoethanol 
• 76397-53-0 3-acetylthiazolidine-2-thione 

Downstream Products

• 1618136-55-2 C₂₄H₂₆N₃O₄⁽¹⁺⁾*C₇H₇O₃S^(1-) 
• 1618136-46-1 C₁₃H₁₉NO₅S 
• 124243-46-5 Benzyl-[2-(2-benzylamino-ethoxy)-ethyl]-[2-(2-ethylamino-ethoxy)-ethyl]-amine 
• 118974-41-7 23-<(allyloxy)methyl>-4,13-dibenzyl-19,28-diethyl-4,13,19,28-tetraza-1,7,10,16,22,25-hexaoxacyclotriacontane 
• 118974-40-6 20-<(allyloxy)methyl>-4,10-dibenzyl-16,25-diethyl-4,10,16,25-tetraza-1,7,13,19,22-pentaoxacycloheptacosane 
• 124243-56-7 N-{2-[2-({2-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethoxy]-ethyl}-benzyl-amino)-ethoxy]-ethyl}-acetamide 
• 124243-55-6 N-[2-(2-{[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide 
• 118974-45-1 {2-[2-(Benzyl-{2-[2-(2-{benzyl-[2-(2-ethylamino-ethoxy)-ethyl]-amino}-ethoxy)-ethoxy]-ethyl}-amino)-ethoxy]-ethyl}-ethyl-amine 
• 119004-92-1 [2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-ethylamino-ethoxy)-ethyl]-amino}-ethoxy)-ethyl]-amino}-ethoxy)-ethyl]-ethyl-amine 
• 118974-37-1 4-<(allyloxy)methyl>-4-benzyl-10,19-diethyl-4,10,19-triaza-1,7,13,16-tetraoxycycloheneicosane 
• 118974-49-5 10-Benzyl-4,16-diethyl-1,7,13-trioxa-4,10,16-triaza-cyclooctadecane-3,17-dione 
• 124266-42-8 N-[2-(2-{Benzyl-[2-(2-benzylamino-ethoxy)-ethyl]-amino}-ethoxy)-ethyl]-acetamide 
• 118974-36-0 4-benzyl-10,16-diethyl-4,10,16-triaza-1,7,13-trioxacyclooctadecane 
• 118974-48-4 N-[2-(2-{[2-(2-Acetylamino-ethoxy)-ethyl]-benzyl-amino}-ethoxy)-ethyl]-acetamide 

Relevant articles and documents

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy

Duchenne muscular dystrophy is a fatal disease with no cure, caused by lack of the cytoskeletal protein dystrophin. Upregulation of utrophin, a dystrophin paralogue, offers a potential therapy independent of mutation type. The failure of first-in-class utrophin modulator ezutromid/SMT C1100 in Phase II clinical trials necessitates development of compounds with better efficacy, physicochemical and ADME properties and/or complementary mechanisms. We have discovered and performed a preliminary optimisation of a novel class of utrophin modulators using an improved phenotypic screen, where reporter expression is derived from the full genomic context of the utrophin promoter. We further demonstrate through target deconvolution studies, including expression analysis and chemical proteomics, that this compound series operates via a novel mechanism of action, distinct from that of ezutromid.

METHOD OF MAKING A COMPOSITION OF AN ALKANOLAMINE ALKYLAMIDE AND A POLYOL

The disclosure generally provides methods for preparing compositions comprising alkanolamine alkylamides and polyols. This disclosure further relates to methods for preparing compositions comprising alkanolamine alkylamides and polyols that can be used in formulations that provide moisturization.

Synthesis and in vitro antitumor activity of novel 2-alkyl-5- methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives

Twenty-one types of novel ellipticine derivatives and pyridocarbazoles (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a nitrosourea moiety, linked by an oxydiethylene unit at the 2 position, were synthesized, and their cytotoxicity against HeLa S-3 cells was evaluated. Some of these new compounds exhibited potent antitumor activity by comparison with that of ellipticine.