1190882-06-4Relevant articles and documents
Synthesis of α-amino amides via N,O-acetals derived from Weinreb amides
Hirner, Sebastian,Somfai, Peter
experimental part, p. 7798 - 7803 (2009/12/29)
(Chemical Equation Presented) An easy and straightforward synthesis of α-amino amides via a base-mediated rearrangement of modified Weinreb amides into N,O-acetals is presented. Subsequent arylation, alkylation, alkenylation, or alkynylation of this intermediate affords the corresponding R-amino amides in excellent yields. Furthermore, a more generalized protocol for the α-arylation of Weinreb amides lacking an R-amino moiety is also discussed.