1191249-23-6

Basic information

• Product Name: (R)-methyl 2-(3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxamido)-4-(methylthio)butanoate
• Synonyms: (R)-methyl 2-(3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxamido)-4-(methylthio)butanoate
• CAS NO: 1191249-23-6
• Molecular Weight: 483.076
• Mol File: 1191249-23-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-methyl 2-(3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxamido)-4-(methylthio)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 2-(3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxamido)-4-(methylthio)butanoate(1191249-23-6)
• EPA Substance Registry System: (R)-methyl 2-(3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxamido)-4-(methylthio)butanoate(1191249-23-6)

Safety Data

• Hazardous Substances Data: 1191249-23-6(Hazardous Substances Data)

Upstream product

• 21691-49-6 D-methionine methyl ester 
• 882281-87-0 C₁₆H₁₄ClNO₂S₂ 
• 882280-82-2 C₁₅H₁₂ClNO₂S₂ 

Downstream Products

• 1191249-24-7 (R)-2-(3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxamido)-4-(methylthio)butanoic acid 

Relevant articles and documents

Introduction of methionine mimics on 3-arylthiophene: Influence on protein farnesyltransferase inhibition and on antiparasitic activity

In the course of our search for new protein farnesyltransferase inhibitors with antiparasitic activity, we found that addition of a methionine residue at position 2 of 3-arylthiophenes greatly improved enzyme inhibition. To investigate the influence of this methionine residue on FTase and antiparasitic activities, 29 novel tetrasubstituted thiophenes bearing methionine or analogous moieties were synthesised. These new derivatives were evaluated on human and Trypanosoma brucei protein farnesyltransferases and on proliferation of 4 protozoan parasites: Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania donovani. Some compounds showed promising low micromolar or submicromolar activities on T. b. brucei and L. donovani confirming the potential of this new class as antiparasitic agents.