119139-18-3

Basic information

• Product Name: 2H-Pyran, tetrahydro-2-(4-methyl-3-nitrophenoxy)-
• CAS NO: 119139-18-3
• Molecular Formula: C12H15NO4
• Molecular Weight: 237.255
• Mol File: 119139-18-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, tetrahydro-2-(4-methyl-3-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, tetrahydro-2-(4-methyl-3-nitrophenoxy)-(119139-18-3)
• EPA Substance Registry System: 2H-Pyran, tetrahydro-2-(4-methyl-3-nitrophenoxy)-(119139-18-3)

Safety Data

• Hazardous Substances Data: 119139-18-3(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 2042-14-0 4-methyl-5-nitrophenol 
• 694-54-2 tetrahydro-2H-2-pyranol 

Downstream Products

• 923595-52-2 2-methyl-5-(tetrahydro-2H-pyran-2-yloxy)aniline 

Relevant articles and documents

Selective tetrahydropyranylation under non-acidic conditions

We report that the tetrahydropyranylation of hydroxyl groups, exhibiting especially very low nucleophilicities, can be achieved by means of Mitsunobu reaction with 2-hydroxytetrahydropyran. This reaction led to the protection of phenols and pyridinols without the use of an acidic catalyst. For instance hydroxypyridines could not be protected by dihydropyran under acidic conditions, whereas they underwent a smooth tetrahydropyranylation under Mitsunobu conditions. The method is selective for a phenol over an alcohol. Georg Thieme Verlag Stuttgart.