1191901-33-3

Basic information

• Product Name: TCO-carbonate
• Synonyms: (E)-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester carbonic acid;(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate;TCO-carbonate;TCO-NHS;TCO-N-hydroxysuccinimidyl carbonate;trans-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl carbonate;TCO-NHS ester
• CAS NO: 1191901-33-3
• Molecular Formula: C13H17NO5
• Molecular Weight: 267.27778
• Mol File: 1191901-33-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 90-105°C
• Boiling Point: 369.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: ?20°C
• CAS DataBase Reference: TCO-carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: TCO-carbonate(1191901-33-3)
• EPA Substance Registry System: TCO-carbonate(1191901-33-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1191901-33-3(Hazardous Substances Data)

Usage

Description

TCO-NHS Ester, also known as a succinimidyl carbonate/NHS functionalized cyclooctene derivative, is a popular reagent used for incorporating the cyclooctene moiety into amine-containing compounds or biomolecules. It enables fast click chemistry with tetrazine, making it a valuable tool in various applications.

Uses

Used in Biological Labeling and Imaging:
TCO-NHS ester is used as a labeling agent for amine-containing compounds or biomolecules, allowing for fast click chemistry with tetrazine. This enables the formation of stable covalent linkages, which is particularly useful in biological labeling and imaging applications.
Used in Strain-Promoted Copper-Free Click Chemistry:
TCO-NHS ester is used as a key component in strain-promoted copper-free click chemistry, where it participates in cycloaddition reactions with 1,2,4,5-tetrazines. This reaction does not require a catalyst and results in a stable covalent linkage, making it an efficient method for various applications in the field of chemistry and biology.
Used in Pharmaceutical and Biomedical Research:
TCO-NHS ester is used as a reagent in the development of new drugs and therapies, as well as in the study of biological processes. Its ability to form stable covalent linkages with tetrazine functionalized compounds or biomolecules makes it a valuable tool for researchers in these fields.