1191908-84-5 Usage
Description
1-(1-isonicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea, also known as Compound 24, is a urea derivative featuring a piperidine ring and a trifluoromethoxyphenyl group. This chemical compound has been investigated for its potential therapeutic applications, particularly in oncology. Its unique structure and properties position it as a promising candidate for the development of novel anticancer drugs.
Uses
Used in Pharmaceutical Industry:
1-(1-isonicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea is used as a kinase inhibitor for its potential role in the treatment of cancer. 1-(1-isonicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea has demonstrated activity against protein kinase C (PKC) and Aurora kinase, which are often dysregulated in various types of cancer. By inhibiting these kinases, Compound 24 may help in controlling tumor growth and progression.
Used in Cancer Research:
In the field of cancer research, 1-(1-isonicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea serves as a valuable tool for studying the mechanisms of action and potential therapeutic effects of kinase inhibitors. Its unique structure allows researchers to explore new avenues in the development of targeted cancer therapies.
Used in Drug Development:
1-(1-isonicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea is utilized in drug development as a lead compound for the creation of new anticancer medications. Its promising activity as a kinase inhibitor makes it a valuable starting point for the design and synthesis of more potent and selective drugs that could be used in the treatment of various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1191908-84-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,1,9,0 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1191908-84:
(9*1)+(8*1)+(7*9)+(6*1)+(5*9)+(4*0)+(3*8)+(2*8)+(1*4)=175
175 % 10 = 5
So 1191908-84-5 is a valid CAS Registry Number.
1191908-84-5Relevant articles and documents
1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: Structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain
Rose, Tristan E.,Morisseau, Christophe,Liu, Jun-Yan,Inceoglu, Bora,Jones, Paul D.,Sanborn, James R.,Hammock, Bruce D.
supporting information; experimental part, p. 7067 - 7075 (2010/12/25)
1,3-Disubstituted ureas possessing a piperidyl moiety have been synthesized to investigate their structure-activity relationships as inhibitors of the human and murine soluble epoxide hydrolase (sEH). Oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors in mice revealed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. For example, 1-(1-(cyclopropanecarbonyl) piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (52) showed a 7-fold increase in potency, a 65-fold increase in Cmax, and a 3300-fold increase in AUC over its adamantane analogue 1-(1-adamantyl)-3-(1-propionylpiperidin-4-yl) urea (2). This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.