1191921-02-4

Basic information

• Product Name: (3R,4R,5S)-ethyl 4-acetamido-5-(benzoylamido)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
• Synonyms: (3R,4R,5S)-ethyl 4-acetamido-5-(benzoylamido)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
• CAS NO: 1191921-02-4
• Molecular Weight: 416.517
• Mol File: 1191921-02-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R,4R,5S)-ethyl 4-acetamido-5-(benzoylamido)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R,5S)-ethyl 4-acetamido-5-(benzoylamido)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate(1191921-02-4)
• EPA Substance Registry System: (3R,4R,5S)-ethyl 4-acetamido-5-(benzoylamido)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate(1191921-02-4)

Safety Data

• Hazardous Substances Data: 1191921-02-4(Hazardous Substances Data)

Upstream product

• 1151665-75-6 (3R,4S,5R)-3-azido-4,5-bis-methanesulfonyloxy-cyclohex-1-enecarboxylic acid ethyl ester 
• 65-85-0 benzoic acid 
• 204255-11-8 oseltamivir phosphate 
• 138-59-0 shikimic acid 
• 1151665-77-8 (1S,5R,6S)-ethyl 7-acetyl-5-((methylsulfonyl)oxy)-7-azabicyclo[4.1.0]hept-2-ene-3-carboxylate 
• 1151665-76-7 ethyl (1S,5R,6S)-5-methanesulfonyloxy-7-azabicyclo[4.1.0]hept-2-ene-3-carboxylate 

Relevant articles and documents

The hydrophobic side chain of oseltamivir influences type A subtype selectivity of neuraminidase inhibitors

Neuraminidase, which plays a critical role in the influenza virus life cycle, is a target for new therapeutic agents. The study of structure–activity relationships revealed that the C-5 position amino group of oseltamivir was pointed to 150-cavity of the neuraminidase in group 1. This cavity is important for selectivity of inhibitors against N1 versus N2 NA. A serial of influenza neuraminidase inhibitors with the oseltamivir scaffold containing lipophilic side chains at the C-5 position have been synthesized and evaluated for their influenza neuraminidase inhibitory activity and selectivity. The results indicated that compound 13o (H5N1 IC50?=?0.1?±?0.04?μm, H3N2 IC50?=?0.26?±?0.18?μm) showed better inhibitory activity and selectivity against the group 1 neuraminidase. This study may provide a clue to design of better group 1 neuraminidase inhibitors.