1192-81-0

Basic information

• Product Name: 5-(CHLOROMETHYL)-3-METHYL-1,2,4-OXADIAZOLE
• Synonyms: 1,2,4-oxadiazole, 5-(chloromethyl)-3-methyl-;5-(chloromethyl)-3-methyl-1,2,4-oxadiazole(SALTDATA: FREE);-3-methyl-1,2,4-oxadiazole
• CAS NO: 1192-81-0
• Molecular Formula: C₄H₅ClN₂O
• Molecular Weight: 132.55
• Mol File: 1192-81-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 211.669 °C at 760 mmHg
• Flash Point: 81.815 °C
• Appearance: /
• Density: 1.291 g/cm³
• Vapor Pressure: 0.262mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: -1.10±0.32(Predicted)
• CAS DataBase Reference: 5-(CHLOROMETHYL)-3-METHYL-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(CHLOROMETHYL)-3-METHYL-1,2,4-OXADIAZOLE(1192-81-0)
• EPA Substance Registry System: 5-(CHLOROMETHYL)-3-METHYL-1,2,4-OXADIAZOLE(1192-81-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1192-81-0(Hazardous Substances Data)

Usage

General Description

5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole is a chemical compound with the molecular formula C4H5ClN2O. It is a white to light yellow crystalline powder that is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole is also known for its potential biological activity and has been studied for its antimicrobial, antiviral, and anticancer properties. It is important to handle this chemical with care, as it is considered hazardous and may cause irritation to the skin, eyes, and respiratory system. Additionally, it should be stored in a cool, dry place and kept away from strong oxidizing agents.

InChI:InChI=1/C4H5ClN2O/c1-3-6-4(2-5)8-7-3/h2H2,1H3

Upstream product

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Downstream Products

• 625446-01-7 1-cyclopentyl-3-{4-[(3-methyl-1,2,4-oxadiazol-5-yl)methoxy]phenyl}propan-1-one 
• 1411980-31-8 2-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-7-(4-(trifluoromethoxy)phenyl)phthalazin-1(2H)-one 
• 1354198-41-6 2-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 1235840-72-8 1-methyl-6-(4-(2-(1-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)piperidin-4-yl)-ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile 
• 14374-19-7 3-methyl-5-(diethoxyphosphorothioylthiomethyl)-1,2,4-oxadiazole 
• 74704-86-2 2,6-diethyl-N-(3'-methyl-1',2',4'-oxadiazol-5'-yl-methyl)-aniline 
• 1411981-26-4 3-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one 

Relevant articles and documents

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit

We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazine (1) as a potent partial agonist for the 0.3 receptor subtype with 5-fold selectivity in binding affinity over α1. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α3 subtype over the α1 subtype was 12-fold (for 57). Although most analogues showed no selectivity in terms of efficacy, some did show partial agonism at α1 and antagonism at α3 (e.g., 25 and 75). However, two analogues tested (93 and 96), both with triazole substituents in the 6-position, showed significantly higher efficacy for the α3 subtype over the α1 subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series.

Substituted oxadiazoles and their use as corn root worm insecticides

A method for killing corn root worms by applying to the soil habitat of the root worms an insecticidal amount of the compound of the formula STR1 wherein R1, R2 and R3 are alkyl of 1 to 4 carbon atoms; and X, Y, Z and V are sulfur or oxygen.