1192010-61-9Relevant articles and documents
An Isoquinolin-1(2H)-Imine Derivative Induces Cell Death via Generation of Reactive Oxygen Species and Activation of JNK in Human A549 Cancer Cells
Liu, Jing,Liu, Tongyang,Mou, Hanchuan,Jia, Shuting,Huang, Chao,Yan, Shengjiao,Lin, Jun,Luo, Ying,Zhang, Jihong
, p. 4394 - 4403 (2017)
Compound 11-benzoyl-10-chloro-7,9-difluoro-6-imino-2,3,4,6-tetrahydro-1H-pyrimido[1,2-b]isoquinoline-8-carbonitrile (HC6h) is a novel polyhalo 1,3-diazaheterocycle fused isoquinolin-1(2H)-imines derivative, which displays good anticancer activity and low
Facile route to 1,3-diazaheterocycle-fused [l,2b]isoquinolin-l(2H)-one derivatives via substitution-cyclization Reactions
Yan, Shengjiao,Huang, Chao,Su, Cunxiang,Ni, Yongfen,Lin, Jun
experimental part, p. 91 - 94 (2010/10/04)
The substitution-cyclization reaction of heterocyclic ketene aminals with polyhalo isophthalonitrile in the presence of I-BuOK to form 1,3-diazaheterocycle fused [1,2-fc]isoquinolin-l(2//)-imines, followed by hydrolysis with 1 N HCl, provides a concise and efficient route for the synthesis of highly functional polyhalo 1,3-diazaheterocycle fused [ 1,2-b]isoquinolin-1 (2H)-ones.
