1192037-87-8 Usage
Description
5-Bromo-1-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole is a complex organic compound that belongs to the class of indoles. It is characterized by the presence of a bromine atom at the 5th position, a methyl group at the 1st position, and a 1,3,2-dioxaborolan-2-yl group at the 2nd position. 5-Bromo-1-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole is a versatile building block in organic synthesis and has potential applications in various fields due to its unique structural features.
Uses
Used in Chemical Synthesis:
5-Bromo-1-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole is used as a synthetic intermediate for the preparation of various organic compounds, particularly those with potential applications in pharmaceuticals, agrochemicals, and materials science. Its unique structural features make it a valuable building block for the development of novel molecules with diverse biological activities.
Used in Iridium N-Heterocyclic Carbene-Catalyzed Carbon-Hydrogen Borylation:
In the field of catalysis, 5-Bromo-1-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole is used as a reactant in iridium N-heterocyclic carbene-catalyzed carbon-hydrogen borylation of arenes by diisopropylaminoborane. This reaction is an important method for the functionalization of aromatic compounds, which can lead to the synthesis of various valuable molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
5-Bromo-1-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structural features allow for the development of novel drugs with improved efficacy and selectivity. The compound can be used in the design and synthesis of new drugs targeting various diseases, including cancer, neurological disorders, and infectious diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 5-Bromo-1-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole can be used as a starting material for the development of new pesticides, herbicides, and insecticides. Its unique structural features can be exploited to design molecules with improved biological activity and selectivity, leading to more effective and environmentally friendly agrochemical products.
Used in Materials Science:
5-Bromo-1-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-indole can also find applications in the field of materials science. Its unique structural features can be utilized in the design and synthesis of novel materials with specific properties, such as optoelectronic materials, sensors, and advanced polymers. These materials can have potential applications in various industries, including electronics, energy, and environmental protection.
Check Digit Verification of cas no
The CAS Registry Mumber 1192037-87-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,2,0,3 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1192037-87:
(9*1)+(8*1)+(7*9)+(6*2)+(5*0)+(4*3)+(3*7)+(2*8)+(1*7)=148
148 % 10 = 8
So 1192037-87-8 is a valid CAS Registry Number.
1192037-87-8Relevant articles and documents
Boron(III)-Catalyzed C2-Selective C?H Borylation of Heteroarenes
Zhong, Qi,Qin, Shengxiang,Yin, Youzhi,Hu, Jiajun,Zhang, Hua
, p. 14891 - 14895 (2018)
A BF3?Et2O-catalyzed C2-selective C?H borylation of indoles with bis(pinacolato)diboron was developed to afford indole-2-boronic acid pinacol esters. A variety of functional groups were tolerated, and other heteroarenes like pyrrole and benzo[b]thiophene were also suitable substrates. An electrophilic substitution mechanism was proposed based on the preliminary mechanistic studies. This novel transformation utilizes simple and cheap BF3?Et2O as catalyst and exhibits unusual C2 regioselectivity, providing a significant non-transition-metal-catalyzed C?H borylation and an efficient method towards the synthesis of C2-functionalized heteroarenes.
Benzoic Acid-Promoted C2-H Borylation of Indoles with Pinacolborane
Zou, Youliang,Zhang, Binfeng,Wang, Li,Zhang, Hua
, p. 2821 - 2825 (2021)
A benzoic acid-promoted C2-H borylation of indoles with pinacolborane to afford C2-borylated indoles is developed. Preliminary mechanistic studies indicate BH3-related borane species formed via the decomposition of pinacolborane to be the probable catalyst. This transformation provides a prompt route toward the synthesis of diverse C2-functionalized indoles.
