1192358-22-7

Basic information

• Product Name: N-(2-azidoethyl)-4-pentylbenzamide
• Synonyms: N-(2-azidoethyl)-4-pentylbenzamide
• CAS NO: 1192358-22-7
• Molecular Weight: 260.339
• Mol File: 1192358-22-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-azidoethyl)-4-pentylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-azidoethyl)-4-pentylbenzamide(1192358-22-7)
• EPA Substance Registry System: N-(2-azidoethyl)-4-pentylbenzamide(1192358-22-7)

Safety Data

• Hazardous Substances Data: 1192358-22-7(Hazardous Substances Data)

Upstream product

• 19263-22-0 1-azido-2-bromoethane 
• 49763-65-7 4-pentylbenzoyl chloride 
• 87156-40-9 1-amino-2-azidoethane 

Downstream Products

• 1192358-52-3 tert-butyl 2-amino-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-34-6 tert-butyl 2-(benzyl(tert-butoxycarbonyl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-35-7 tert-butyl 2-((tert-butoxycarbonyl)(4-butylbenzyl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-36-8 tert-butyl 2-((tert-butoxycarbonyl)(3-(trifluoromethyl)benzyl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-38-0 C₄₃H₅₉N₇O₅ 
• 1415901-39-1 tert-butyl 4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-2-(pyrrolidin-1-yl)-1H-imidazole-1-carboxylate 
• 1415901-24-4 tert-butyl 2-((tert-butoxycarbonyl)(methyl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-25-5 tert-butyl 2-((tert-butoxycarbonyl)methylsulfonamido)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-26-6 tert-butyl 2-((tert-butoxycarbonyl)(isopropyl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-28-8 tert-butyl 2-((tert-butoxycarbonyl)(hexyl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-27-7 tert-butyl 2-(allyl(tert-butoxycarbonyl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-29-9 tert-butyl 2-((tert-butoxycarbonyl)(heptan-2-yl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 
• 1415901-31-3 tert-butyl 2-((tert-butoxycarbonyl)(2-(2-methoxyethoxy)ethyl)amino)-4-(5-(1-(2-(4-pentylbenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 

Relevant articles and documents

N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization

Antibiotic resistance is a significant problem and is compounded by the ability of many pathogenic bacteria to form biofilms. A library of N-substituted derivatives of a previously reported 2-aminoimidazole/triazole (2-AIT) biofilm modulator was constructed via α-bromoketone cyclization with 1,3-bis(tert-butoxycarbonyl)guanidine, followed by selective substitution. Several compounds exhibited the ability to inhibit biofilm formation by three strong biofilm forming strains of methicillin resistant Staphylococcus aureus (MRSA). Additionally, a number of members of this library exhibited synergistic activity with oxacillin against planktonic MRSA. Compounds with this type of dual activity have the potential to be used as adjuvants with conventional antibiotics. The Royal Society of Chemistry.

INHIBITION AND DISPERSION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-TRIAZOLE DERIVATIVES

Disclosure is provided for imidazole-triazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.