1192581-56-8Relevant articles and documents
Trivalent metal complex geometry of the substrate governs cathepsin B enzymatic cleavage rate
Ahn, Shin Hye,Boros, Eszter,Iuliano, James N.
supporting information, p. 7289 - 7292 (2020/07/23)
The lysosomal protease cathepsin B recognizes defined, short peptide sequences, providing means for effective, targeted drug release. Here, we show that the introduction of a coordination complex adjacent to the cleavage sequence allows us to tune enzymatic cleavage rate by varying the complexed, trivalent metal ion.
