119262-68-9

Basic information

• Product Name: scutellarin Methylester
• Synonyms: 5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid methyl ester;scutellarin Methylester;Scutellarin Methlester
• CAS NO: 119262-68-9
• Molecular Formula: C₂₂H₂₀O₁₂
• Molecular Weight: 476.387
• EINECS: 300-008-1
• Product Categories: reagent;standard substance;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 119262-68-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 804.0±65.0 °C(Predicted)
• Appearance: /
• Density: 1.697±0.06 g/cm3(Predicted)
• PKA: 5.92±0.40(Predicted)
• CAS DataBase Reference: scutellarin Methylester(CAS DataBase Reference)
• NIST Chemistry Reference: scutellarin Methylester(119262-68-9)
• EPA Substance Registry System: scutellarin Methylester(119262-68-9)

Safety Data

• Hazardous Substances Data: 119262-68-9(Hazardous Substances Data)

Usage

Effect

The improvement effect of scutellarin methylester on ischemic brain tissue showed that scutellarin methylester can effectively improve the local cerebral blood flow of ischemia-reperfusion in rats, and significantly reduce the degree of ischemic damage to brain tissue. The mechanism may be In order to inhibit cerebral vasospasm caused by protein kinase activation, increase local cerebral blood flow, improve cerebral microcirculation, and reduce inflammatory cell adhesion and infiltration, thereby reducing brain damage.

Mechanism of action

Scutellarin methylester mainly inhibits the formation of thrombus in vitro through three steps, reducing platelet count, inhibiting platelet aggregation function, inhibiting coagulation function in vivo, and promoting fibrinolytic activity, of which the latter two have stronger effects.

Upstream product

• 67-56-1 methanol 
• 27740-01-8 scutellarin 
• 13165-72-5 chlorosulfite de methyle 
• 529-53-3 scutellarein 
• 54917-66-7 5,6,4'-triacetoxy-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1180-46-7 4,5,6,7-tetra-O-acetylflavone 

Downstream Products

• 27740-01-8 scutellarin 
• 529-53-3 scutellarein 
• 70938-59-9 methyl 3,4,5-trihydroxy-6-((5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-carboxylate 
• 35536-70-0 scutellarein 4'-O-methyl-7-O-β-D-glucopyranoside 
• 54917-66-7 5,6,4'-triacetoxy-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1432474-23-1 C₃₆H₃₇NO₁₅ 
• 1432474-22-0 C₃₂H₃₇NO₁₅ 
• 1432474-21-9 C₃₀H₃₃NO₁₅ 
• 1432474-25-3 C₃₅H₄₁NO₁₇ 
• 1432474-24-2 C₃₆H₄₃NO₁₇ 

Relevant articles and documents

PEG-scutellarin prodrugs: Synthesis, water solubility and protective effect on cerebral ischemia/reperfusion injury

Fifteen PEG-scutellarin prodrugs were synthesized by modifying carboxyl and phenolic hydroxyl groups of scutellarin with mPEG of different molecular weight (400-3000). The water solubility of prodrugs increased remarkably and reached the maximum value of

Preparation method of homoplantaginin

The invention relates to the field of chemical synthesis, in particular to a novel preparation method of homoplantaginin. The method employs scutellarin as a raw material and can be used for efficiently semi-synthesizing the homoplantaginin from the scutellarin through three steps of reactions of carboxyl esterification, selective methylation and ester group reduction. The method is short in reaction step, high in reaction yield, mild in reaction condition and easy to operate, provides a necessary material basis for further research on the biological activity of the homoplantaginin, and has arelatively good application and development prospect.

An efficient, scalable approach to hydrolyze flavonoid glucuronides via activation of glycoside bond

Hydrolyzing flavonoid glucuronides into corresponding aglycones posed some significant challenges. To improve acid-catalyzed hydrolysis process of flavonoid glucuronide, structures of glucuronide, hydrolysis parameters and post-processing were optimized. The optimized condition was performed by hydrolysis flavonoid glycoside methyl ester in a mixed solvent consisting of 2?mol/L H2SO4/EtOH/H2O (1/8/1, v/v/v) at 95?°C for 7?h and resulted in up to 90% aglycone yields, minimal byproduct formations and milder hydrolysis conditions. Furthermore, the optimized method avoids tedious purification steps and is easily conducted on a relatively large-scale using economical and commercially available reagents.