119416-26-1

Basic information

• Product Name: 4-BROMO-2,6-DIMETHYL-N-ACETYLANILINE
• Synonyms: 4-BROMO-2,6-DIMETHYL-N-ACETYLANILINE;SALOR-INT L168351-1EA;N-(4-Bromo-2,6-Dimethylphenyl)Acetamide;N-(4-Bromo-2,6-dimethylphenyl)
• CAS NO: 119416-26-1
• Molecular Formula: C₁₀H₁₂BrNO
• Molecular Weight: 242.11
• Mol File: 119416-26-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 331.1 °C at 760 mmHg
• Flash Point: 154.1 °C
• Appearance: /
• Density: 1.413 g/cm³
• Vapor Pressure: 0.000159mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: 2-8°C
• PKA: 14.26±0.70(Predicted)
• CAS DataBase Reference: 4-BROMO-2,6-DIMETHYL-N-ACETYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2,6-DIMETHYL-N-ACETYLANILINE(119416-26-1)
• EPA Substance Registry System: 4-BROMO-2,6-DIMETHYL-N-ACETYLANILINE(119416-26-1)

Safety Data

• Hazardous Substances Data: 119416-26-1(Hazardous Substances Data)

Usage

General Description

4-Bromo-2,6-dimethyl-N-acetylaniline is a chemical compound with the molecular formula C11H14BrNO. It is a derivative of aniline with a bromine atom and two methyl groups attached to the benzene ring, as well as an N-acetyl group attached to the amine group. 4-BROMO-2,6-DIMETHYL-N-ACETYLANILINE is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of dyes and pigments. 4-Bromo-2,6-dimethyl-N-acetylaniline is a yellow to brown solid that is considered to be potentially hazardous, and caution should be taken when handling and using this compound.

InChI:InChI=1/C10H12BrNO/c1-6-4-9(11)5-7(2)10(6)12-8(3)13/h4-5H,1-3H3,(H,12,13)

Upstream product

• 75-05-8 acetonitrile 
• 87-62-7 2,6-dimethylaniline 
• 166541-50-0 O-benzoyl-N-acetyl-N-(2,6-dimethylphenyl)hydroxylamine 
• 24596-19-8 4-bromo-2,6-dimethylphenylamine 
• 108-24-7 acetic anhydride 
• 2198-53-0 N-(2,6-dimethylphenyl)acetamide 

Relevant articles and documents

Synthesis of Arylamides via Ritter-Type Cleavage of Solid-Supported Aryltriazenes

A novel route for the synthesis of N-arylamides via the cleavage of aryltriazenes with alkyl or aryl nitriles is presented. We developed a variation of the Ritter reaction that allows the use of acetonitrile as solvent and reagent in reactions with solid-supported precursors. The reaction was optimized for the generation of N-aryl acetamides using a diverse range of immobilized building blocks including o-, m-, and p-substituted aryltriazenes. The cleavage via the Ritter-type conversion was combined with an on-bead cross-coupling reaction of halogen-substituted aryltriazenes with pyrazoles. Additionally, the synthesis of on-bead generated arylboronic ester-substituted triazenes was shown. The developed procedure was further expanded to use other commercially available nitriles, such as acrylonitrile, benzonitrile, and chlorinated alkyl nitriles as suitable reagents for a Ritter-type cleavage of the prepared triazene linkers.

Oxidative Bromination of Aromatic Amides using Sodium Perborate as Oxidant

Sodium perborate in glacial acetic acid-acetic anhydride with potassium bromide and sodium tungstate as a catalyst, provides a novel system for the bromination of aromatic amides.