1194374-23-6Relevant articles and documents
Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity
Qian, Yong,Schürmann, Marc,Janning, Petra,Hedberg, Christian,Waldmann, Herbert
, p. 7766 - 7771 (2016)
Woodward's reagent K (WRK) is a reactive heterocyclic compound that has been employed in protein chemistry to covalently and unspecifically label proteins at nucleophilic amino acids, notably at histidine and cysteine. We have developed a panel of WRK-der
Preparation method of isoxazole derivative
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Paragraph 0096-0101, (2019/12/02)
The invention relates to a preparation method of an isoxazole derivative, which comprises the following steps of mixing an propargyl alcohol derivative, a halogen source, an acid and a solvent, and heating to react; adding the hydroxylamine into the react
Gold(III)-catalyzed synthesis of isoxazoles by cycloisomerization of α,β-acetylenic oximes
Praveen,Kalyanasundaram,Perumal
experimental part, p. 777 - 781 (2010/06/12)
Cycloisomerization of,-acetylenic oximes leading to substituted isoxazoles was achieved using AuCl3 as catalyst, under moderate reaction conditions. The reaction can be applied to various acetylenic oximes and gives good to excellent yields. Th