1194476-52-2Relevant articles and documents
Copper-catalyzed asymmetric 1,4-hydroboration of coumarins with pinacolborane: Asymmetric synthesis of dihydrocoumarins
Kima, Hyohyun,Yuna, Jaesook
supporting information; experimental part, p. 1881 - 1885 (2010/10/20)
An efficient asymmetric addition of pinacolborane to 4-substituted coumarins proceeded with high enantioselectivity in the presence of a copper(I)-QuinoxP complex as a catalyst to produce the corresponding 1,4-hydroboration products. Treatment of the intermediates with electrophiles, without isolation, resulted in enantioenriched dihydrocoumarins. The utility of this protocol was demonstrated in the formal synthesis of biologically active molecules.
