119520-06-8Relevant articles and documents
A method for synthesizing uneven handkerchief Trow hydrochloric acid
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Paragraph 0028; 0030; 0031, (2017/03/08)
An embodiment of the invention provides a method for synthesizing zilpaterol Hydrochloride, belonging to a medical synthesizing technology field. The method comprises: resolving 4,5,6,7-tetrahydro-6- hydroximino-imidazo[4,5,1-jk]-[1] benzoaza-2,7(1H,6H)-dione into a mixed solvent of methanol and DMF, adding the mixed solvent and a first catalyst together into a reactor, displacing air in the reactor through nitrogen and hydrogen, filling hydrogen into the reactor, stirring and raising temperature until the temperature is 30-50 DEG C and hydrogen pressure is 1-10 MPa, reacting for 4-24h, filtrating and recovering the catalyst after the reaction; and processing the filtrate through enamine forming, hydrogenation reduction, salt forming, crystallization and hydrochloride forming to obtain the zilpaterol Hydrochloride. The synthetic method of the zilpaterol Hydrochloride utilizes methanol and DMF as reaction solvents to raise a reaction rate, and the method provided by the invention can reduce hydrogenation reaction time below 12h.
PROCESS FOR MAKING A CRYSTALLINE ZILPATEROL SALT
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Page/Page column 23; 24, (2010/08/05)
This invention generally relates to processes for making a crystalline zilpaterol salt, particularly zilpaterol hydrochloride. This invention also relates to methods of treatment using a crystalline zilpaterol salt prepared in accordance with this invention to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.
Synthesis and pharmacological characterization of β2- adrenergic agonist enantiomers: Zilpaterol
Kern, Christopher,Meyer, Thorsten,Droux, Serge,Schollmeyer, Dieter,Miculka, Christian
experimental part, p. 1773 - 1777 (2010/01/16)
The β-adrenergic agonist 1 (zilpaterol) is used as production enhancer in cattle. Binding experiments of separated enantiomers on recombinant human β2-adrenergic and μ-opioid receptors and functional studies showed that the (-)-1 enantiomer acc