119584-79-1 Usage
General Description
8-Fluoro-quinazoline-2,4-diamine, also known as AG-494, is a chemical compound that belongs to the quinazoline class of compounds. It is a potent and selective inhibitor of the catalytic activity of the epidermal growth factor receptor (EGFR) tyrosine kinase, which plays a key role in the regulation of cell growth and survival. 8-Fluoro-quinazoline-2,4-diamine has shown promising potential as an anticancer agent, particularly in the treatment of non-small cell lung cancer and other solid tumors. It works by blocking the activation of EGFR, which in turn inhibits the downstream signaling pathways involved in cancer cell proliferation and survival. Research on this compound continues to explore its therapeutic potential and possible applications in personalized medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 119584-79-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,5,8 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 119584-79:
(8*1)+(7*1)+(6*9)+(5*5)+(4*8)+(3*4)+(2*7)+(1*9)=161
161 % 10 = 1
So 119584-79-1 is a valid CAS Registry Number.
119584-79-1Relevant articles and documents
Direct Synthesis of 2,4-Diaminoquinazolines from 2-Fluorobenzonitriles
Hynes, John B.,Pathak, Alpana,Panos, Constantina H.,Okeke, Claudia C.
, p. 1173 - 1177 (2007/10/02)
In a search for new methods for preparing 2,4-diaminoquinazolines having a diversity of substituents in the benzenoid ring, it was found that the reaction of 2,6-difluorbenzonitrile with guanidine carbonate gave 2,4-diamino-5-fluoroquinazoline in excellent yield.Extension of this approach to other 2-fluorobenzonitriles, some of which were elaborated for the first time, showed that this reaction possesses considerable generality.The cyclization was sucessful even when electron donating groups were present at position six.Only in two cases where a primary or secondary amino group was also present ortho to the cyano group was this transformation unsucessful.
