1195931-66-8Relevant articles and documents
Single-Molecule Imaging of Active Mitochondrial Nitroreductases Using a Photo-Crosslinking Fluorescent Sensor
Thiel, Zacharias,Rivera-Fuentes, Pablo
, p. 11474 - 11478 (2019)
Many biomacromolecules are known to cluster in microdomains with specific subcellular localization. In the case of enzymes, this clustering greatly defines their biological functions. Nitroreductases are enzymes capable of reducing nitro groups to amines,
A mitochondria-targeted red-emitting probe for imaging hydrogen sulfide in living cells and zebrafish
Ismail, Ismail,Wang, Dan,Wang, Dawei,Niu, Cuili,Huang, Haojie,Yi, Long,Xi, Zhen
, p. 3389 - 3395 (2019)
Hydrogen sulfide (H2S) is an important endogenous signaling molecule with multiple biological functions. Based on the thiolysis of NBD (7-nitro-1,2,3-benzoxadiazole) amine, herein we rationally design and synthesize a new fluorescent probe 1 for the detection of mitochondrial H2S in living cells. Probe 1 displays bright red-emitting fluorescence after H2S activation (φ, 0.77). 1 shows higher selectivity and sensitivity for H2S than the red-emitting probe Rho-NBD (ChemBioChem, 2016, 17, 962). Moreover, 1 is water-soluble, cell-membrane-permeable, of low cytotoxicity and mitochondria-targeting, and can be employed for monitoring mitochondrial H2S in living cells.
Coal-Tar Dye-based Coordination Cages and Helicates
Regeni, Irene,Chen, Bin,Frank, Marina,Baksi, Ananya,Holstein, Julian J.,Clever, Guido H.
supporting information, p. 5673 - 5678 (2021/02/03)
A strategy to implement four members of the classic coal-tar dye family, Michler's ketone, methylene blue, rhodamine B, and crystal violet, into [Pd2L4] self-assemblies is introduced. Chromophores were incorporated into bis-monodentate ligands using piperazine linkers that allow to retain the auxochromic dialkyl amine functionalities required for intense colors deep in the visible spectrum. Upon palladium coordination, ligands with pyridine donors form lantern-shaped dinuclear cages while quinoline donors lead to strongly twisted [Pd2L4] helicates in solution. In one case, single crystal X-ray diffraction revealed rearrangement to a [Pd3L6] ring structure in the solid state. For nine examined derivatives, showing colors from yellow to deep violet, CD spectroscopy discloses different degrees of chiral induction by an enantiomerically pure guest. Ion mobility mass spectrometry allows to distinguish two binding modes. Self-assemblies based on this new ligand class promise application in chiroptical recognition, photo-redox catalysis and optical materials.