1196-29-8

Basic information

• Product Name: 1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME
• Synonyms: 2'-HYDROXYACETOPHENONE OXIME;1-(2-HYDROXYPHENYL)-1-ETHANONE OXIME;1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME;O-HYDROXYACETOPHENONE OXIME;1-(2-Hydroxyphenyl)ethanone oxime;2-HydroxyacetophenoxiMe;Methyl 2-Hydroxyphenyl KetoxiMe;(Z)-1-(2-hydroxyphenyl)ethanone oxiMe
• CAS NO: 1196-29-8
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16
• EINECS: 214-810-9
• Product Categories: Metal Isotopes;Aromatics
• Mol File: 1196-29-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 113-115°C
• Boiling Point: 297.1°Cat760mmHg
• Flash Point: 133.5°C
• Appearance: /
• Density: 1.246g/cm³
• Vapor Pressure: 0.000141mmHg at 25°C
• Refractive Index: 1.591
• Solubility: Acetone, Chloroform, Dichloromethane, Ethyl Acetate
• PKA: 9.22±0.35(Predicted)
• CAS DataBase Reference: 1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME(1196-29-8)
• EPA Substance Registry System: 1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME(1196-29-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1196-29-8(Hazardous Substances Data)

Usage

Description

1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME, also known as 2'-Hydroxyacetophenone Oxime, is an off-white solid compound with the CAS number 1196-29-8. It is a versatile organic synthesis intermediate that can be utilized in various chemical reactions to produce a range of products.

Uses

Used in Organic Synthesis:
1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME is used as an intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows it to participate in a wide range of reactions, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME is used as a key intermediate in the synthesis of certain drugs. Its presence in the molecular structure can impart specific biological activities, making it an essential component in the development of new therapeutic agents.
Used in Agrochemical Industry:
1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME also finds application in the agrochemical industry, where it is used as a precursor in the synthesis of various pesticides and other crop protection agents. Its ability to form stable derivatives makes it a suitable candidate for the development of effective and environmentally friendly agrochemicals.
Used in Specialty Chemicals:
In the specialty chemicals sector, 1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME is employed as a raw material for the production of dyes, pigments, and other colorants. Its chemical properties enable it to form stable complexes with various substrates, resulting in vibrant and long-lasting colors.
Overall, 1-(2-HYDROXYPHENYL)ETHAN-1-ONE OXIME is a versatile compound with a wide range of applications across different industries, primarily due to its unique chemical properties and its ability to participate in various organic synthesis processes.

InChI:InChI=1/C8H9NO2/c1-6(9-11)7-4-2-3-5-8(7)10/h2-5,9,11H,1H3/b7-6+

Upstream product

• 75632-99-4 3-methyl-1,2-benzisoxazole N-oxide 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 118-93-4 o-hydroxyacetophenone 
• 108-95-2 phenol 
• 122-79-2 Phenyl acetate 
• 33973-15-8 2a,7b-Dihydro-2a,7b-dimethyl-1,2-dioxeto<3,4-b>benzofuran 

Downstream Products

• 614-80-2 2-(acetylamino)phenol 
• 1862-88-0 N-methylsalicylamide 
• 261356-06-3 Ru(P(C₆H₅)3)2(C₇H₄CH₃NO)Cl₂ 
• 54758-75-7 1-(2-hydroxyphenyl)ethanone O-acetyl oxime 
• 84395-93-7 1,2-benzisoxazole-3-carboxaldehyde 
• 1621019-18-8 3-(benzo[d]isoxazol-3-yl)-1-cyclohexylpyrrolidine-2,5-dione 
• 1621019-19-9 3-(benzo[d]isoxazol-3-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione 
• 1621019-20-2 3-(benzo[d]isoxazol-3-yl)-1-(4-chlorophenyl)pyrrolidine-2,5-dione 
• 1621019-21-3 3-(benzo[d]isoxazol-3-yl)-1-(4-methoxyphenyl)pyrrolidine-2,5-dione 
• 1621019-22-4 3-(benzo[d]isoxazol-3-yl)-1-phenylpyrrolidine-2,5-dione 

Relevant articles and documents

A novel heterometallic 3d-4f complex with an unusual [MnIV 4Nd4O4] core topology

The complex [Mn4Nd4O4(Me-sao) 6(NO3)4(OMe)4(MeOH)2] (1) with an unprecedented [MnIV4Nd4O4] core topology was synthesized from MnCl2, Nd(NO3) 3 and Me-saoH2 in methanol at basic conditions (Me-saoH2 = 2′-hydroxyacetophenoxime). In 1 MnIV and NdIII ions are bridged by oxido and methoxido ligands to form an unusual topology including two distorted tetrahedral [Nd2Mn 2(μ4-O)] units. 1 crystallizes in the monoclinic space group P21/c with Z = 2 and lattice constants (at 100 K) a = 14.142(4), b = 19.365(5), c = 14.637(4) A, β = 90.32(3)°. Copyright

Moessbauer and electronic spectral studies of iron(III) complexes of oximes.

The hydroxo-bridge complexes of the type [Fe(2)(ligand-H)(4)(OH)(2)] with bidentate nitrogen-oxygen donor ligands, viz. 2-hydroxynaphthaldehydeoxime [hnoH(2)], 2-hydroxyacetphenoneoxime [haoH(2)], salicylaldooxime [SalH(2)], 2-hydroxypropiophenoneoxime [hnoH(2)] have been prepared. All the complexes have been characterized by elemental analysis, magnetic moments, electronic and Moessbauer spectral studies. Moessbauer parameters of the complexes clearly suggest high spin configuration of Fe(III) showing lower magnetic moment to that of the spin only value, i.e. 5.92 BM. It may be due to the antiferromagnetic interaction between Fe(III) centers.

Fe(NO3)3·9H2O-catalyzed aerobic oxidative deoximation of ketoximes and aldoximes under mild conditions

A mild, simple process for the effective aerobic oxidative deoximation of a wide range of ketoximes and aldoximes has been developed that utilizes Fe(NO3)3·9H2O as the single catalyst and molecular oxygen as the green oxidant. The environmentally benign protocol provides moderate to excellent yield and broad functional groups tolerance and is a valuable synthetic method for practical applications. According the relevant verification experiment, a plausible mechanism has been proposed.

Acid Catalyzed Direct-Amidation-Dehydrocyclization of 2-Hydroxy-acetophenones to Benzoxazoles by a One-Pot Sustainable Synthesis

A series of 2-methyl-benzoxazoles have been synthesized starting from 2-hydroxy-acetophenones via a one-pot three steps reaction. Hydroxylamonium salt has been used as amidation agent. The reaction occurs with different anions, but the best results is achieved with hydroxylamonium hydrchloride. Despite the number of consecutive stages, the reaction is highly selective. Mild reaction conditions and various solvents can be used, but trifluoroacetic acid is the preferred. Almost, complete recovery of the trifluoroacetic acid can be achieved by vacuum distillation. The role of trifluoroacetic acid, as well as, of the hydroxylamonium salt suggests a cooperative effect leading to high selective formation of 2-methyl-benzoxazoles. Graphical Abstract: One-pot TFA catalyzed synthesis of benzoxazoles starting from 2-hydroxyacetophenones. (Chemical Equation Presented).