1196156-42-9

Basic information

• Product Name: Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate
• Synonyms: Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate;1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, Methyl ester
• CAS NO: 1196156-42-9
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16008
• Mol File: 1196156-42-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate(1196156-42-9)
• EPA Substance Registry System: Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate(1196156-42-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1196156-42-9(Hazardous Substances Data)

Usage

General Description

Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate is a chemical compound with the molecular formula C9H7N3O2. It belongs to the pyrazolo[3,4-b]pyridine-5-carboxylate family and is commonly used in organic synthesis and pharmaceutical research. Methyl 1H-pyrazolo[3,4-b]pyridine-5-carboxylate is known for its potential therapeutic properties and is being studied for its potential applications in drug discovery. It is commonly used as a building block in the synthesis of various pharmaceutical compounds, and its unique structure and properties make it a valuable tool for medicinal chemistry research. Additionally, it is important to handle this chemical compound with caution and adhere to proper safety protocols due to its potential health hazards.

Upstream product

• 67-56-1 methanol 
• 875781-17-2 5-bromo-7-azaindazole 
• 201230-82-2 carbon monoxide 
• 952182-02-4 1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid 
• 875781-15-0 5-bromo-2-fluoro-3-pyridinecarboxaldehyde 
• 1234616-67-1 1H-pyrazolo[3,4-b]pyridine-5-carbonitrile 

Downstream Products

• 1581701-34-9 N-(2-methyl-5-((4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 952182-02-4 1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid 

Relevant articles and documents

Zinc Acetate-Promoted Buchwald-Hartwig Couplings of Heteroaromatic Amines

Zinc salts have been shown to promote the Buchwald-Hartwig coupling of azaindoles and azaindazoles with heteroaryl chlorides to provide the corresponding 1-aryl-1H-azaindoles and 1-aryl-1H-azaindazoles. The substrate scope and mechanistic aspects of this reaction were explored.

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

Caseinolytic protease P (ClpP) is an important regulator of Staphylococcus aureus pathogenesis. A high-throughput screening for inhibitors of ClpP peptidase activity led to the identification of the first non-covalent binder for this enzyme class. Co-crystallization of the small molecule with S. aureus ClpP revealed a novel binding mode: Because of the rotation of the conserved residue proline 125, ClpP is locked in a defined conformational state, which results in distortion of the catalytic triad and inhibition of the peptidase activity. Based on these structural insights, the molecule was optimized by rational design and virtual screening, resulting in derivatives exceeding the potency of previous ClpP inhibitors. Strikingly, the conformational lock is overturned by binding of ClpX, an associated chaperone that enables proteolysis by substrate unfolding in the ClpXP complex. Thus, regulation of inhibitor binding by associated chaperones is an unexpected mechanism important for ClpP drug development.

GPR40 RECEPTOR AGONIST, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a novel compound having GPR40 receptor agonist activity that promotes insulin secretion and inhibits blood sugar rise after glucose loading, and is thereby useful for the treatment of diabetes and complications thereof, the preparation method thereof and pharmaceutical composition containing them as an active ingredient.