1196388-86-9Relevant articles and documents
Discovery of potent, selective and orally bioavailable imidazo[1,5-a] pyrazine derived ACK1 inhibitors
Jin, Meizhong,Wang, Jing,Kleinberg, Andrew,Kadalbajoo, Mridula,Siu, Kam W.,Cooke, Andrew,Bittner, Mark A.,Yao, Yan,Thelemann, April,Ji, Qunsheng,Bhagwat, Shripad,Mulvihill, Kristen M.,Rechka, Josef A.,Pachter, Jonathan A.,Crew, Andrew P.,Epstein, David,Mulvihill, Mark J.
, p. 979 - 984 (2013)
This Letter describes the medicinal chemistry effort towards a series of novel imidazo[1,5-a]pyrazine derived inhibitors of ACK1. Virtual screening led to the discovery of the initial hit, and subsequent exploration of structure-activity relationships and
