119671-47-5

Basic information

• Product Name: 2-CHLORO-6-MORPHOLINOPYRAN-4-ONE
• Synonyms: 2-CHLORO-6-MORPHOLINOPYRAN-4-ONE;2-chloro-6-morpholin-4-ylpyran-4-one
• CAS NO: 119671-47-5
• Molecular Formula: C₉H₁₀ClNO₃
• Molecular Weight: 215.6336
• EINECS: -0
• Mol File: 119671-47-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 373.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly)
• PKA: 0.05±0.20(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-MORPHOLINOPYRAN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-MORPHOLINOPYRAN-4-ONE(119671-47-5)
• EPA Substance Registry System: 2-CHLORO-6-MORPHOLINOPYRAN-4-ONE(119671-47-5)

Safety Data

• Hazardous Substances Data: 119671-47-5(Hazardous Substances Data)

Usage

Description

2-Chloro-6-morpholinopyran-4-one is a chemical compound that has been identified for its potential as a DNA-dependent protein kinase (DNA-PK) inhibitor and Ataxia Telangiectasia Mutated (ATM) kinase inhibitor. These properties make it a promising candidate for research and development in the field of medicinal chemistry, particularly for the treatment of various diseases and conditions that involve DNA repair mechanisms.

Uses

Used in Pharmaceutical Research:
2-Chloro-6-morpholinopyran-4-one is used as a research compound for its potential as a DNA-dependent protein kinase (DNA-PK) inhibitor and Ataxia Telangiectasia Mutated (ATM) kinase inhibitor. Its ability to inhibit these kinases makes it a valuable tool in studying the role of these enzymes in DNA repair and other biological processes.
Used in Cancer Therapy Development:
In the field of oncology, 2-chloro-6-morpholinopyran-4-one is being investigated for its potential use as a therapeutic agent in cancer treatment. Its inhibitory effects on DNA-PK and ATM kinases may help in targeting cancer cells with high genomic instability, thereby enhancing the effectiveness of radiotherapy and chemotherapy.
Used in Radioprotection:
Due to its inhibitory effects on DNA repair mechanisms, 2-chloro-6-morpholinopyran-4-one may also have applications in radioprotection. By inhibiting the DNA repair enzymes, it could potentially protect normal cells from the damaging effects of radiation while leaving cancer cells more susceptible to radiation-induced damage.
Used in Neurodegenerative Disease Research:
Given the involvement of DNA repair mechanisms in neurodegenerative diseases, 2-chloro-6-morpholinopyran-4-one may also be explored for its potential role in the treatment or management of such conditions. Its ability to modulate DNA repair pathways could provide insights into the development of therapeutic strategies for diseases like Alzheimer's and Parkinson's.

Upstream product

• 81189-95-9 4-chloro-4-(2,2,2-trichloroethyl)-oxetan-2-one 
• 85839-49-2 4,4-dichloro-1-(morpholin-4-yl)but-3-ene-1,2-dione 

Downstream Products

• 587871-26-9 2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one 
• 587871-32-7 2-(2-Phenylsulfanyl-phenyl)-6-morpholin-4-yl-pyran-4-one 

Relevant articles and documents

2,4,6-TRIS(DIALKYLAMINO)PYRYLIUM SALTS AND RELATED SYSTEMS, SYNTHESIS AND REACTION BEHAVIOUR

2,4,6-Tris(dialkylamino)pyrylium salts 9 and 2,6-bis(dialkylamino)-pyran-4-ones 11 as well as their thio-analogues 10, 12 have been prepared by a multi-step route starting with 1,1,5,5-tetrachloro-penta-1,4-dien-3-one(1).The tris(dialkylamino)-substituted 9, 10 undergo electrophilic substitution.They are better represented as polymethine-like systems.The 2,6-bis(dialkylamino)-substituted 11, 12 display a significantly increased donor-reactivity at the carbonyl-oxygen.

ATM inhibitors

The application concerns a compound of formula I: wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3 group; Y is either O or S; R1