119702-51-1

Basic information

• Product Name: (E)-5-styryltetrahydrofuran-2(3H)-one
• Synonyms: (E)-5-styryltetrahydrofuran-2(3H)-one
• CAS NO: 119702-51-1
• Molecular Weight: 188.226
• Mol File: 119702-51-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-5-styryltetrahydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-styryltetrahydrofuran-2(3H)-one(119702-51-1)
• EPA Substance Registry System: (E)-5-styryltetrahydrofuran-2(3H)-one(119702-51-1)

Safety Data

• Hazardous Substances Data: 119702-51-1(Hazardous Substances Data)

Upstream product

• 112607-22-4 (+)-(R)-5-(2-phenylethyl)dihydrofuran-2(3H)-one 
• 13122-67-3 6-phenyl-4-oxohexanoic acid 
• 1387517-39-6 (E)-1-(methoxycarbonyl)-2-styrylcyclopropanecarboxylic acid 
• 10374-51-3 5-hydroxymethyl-4,5-dihydrofuranone 
• 100-39-0 benzyl bromide 
• 27620-83-3 4-hydroxy-5-oxopentanoic acid lactone 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 130719-19-6 (E)-2-styrylcyclobutanone 
• 540803-87-0 6-phenylhex-5-ynoic acid 
• 625-38-7 but-3-enoic acid 
• 42599-24-6 E-styryl iodide 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 14371-10-9 (E)-3-phenylpropenal 
• 35573-93-4 3-chloro-1,1-diethoxy-propane 

Downstream Products

• 1449123-30-1 (R)-5-((4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl)furan-2(5H)-one 
• 1449123-31-2 (-)-(3aS,5R,6S,6aS)-6-hydroxy-5-phenyltetrahydrofuro[3,2-b]furan-2(5H)-one 
• 1449123-29-8 (R)-5-((4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl)dihydrofuran-2(3H)-one 

Relevant articles and documents

Suppression of β-hydride elimination in the intramolecular hydrocarboxylation of alkynes leading to the formation of lactones

Palladium-catalyzed intramolecular cyclization of the alkynoic acids was studied which gave the five- and six-membered lactones in moderate yields. The reaction can be conducted simply by heating a toluene solution of alkynoic acids at 100 °C in the prese

Design, synthesis, in vitro cytotoxicity evaluation and structure-activity relationship of Goniothalamin analogs

A series of six/five member (E/Z)-Goniothalamin analogs were synthesized from commercially available (3,4-dihydro-2H-pyran-2-yl)methanol/5- (hydroxymethyl)dihydrofuran-2(3H)-one in three steps with good to moderate overall yields and their cytotoxicity against lymphoblastic leukemic T cell line (Jurkat E6.1) have been evaluated. Among the synthesized analogs, (Z)-Goniothalamin appeared to be the most active in cytotoxicity (IC 50 = 12 μM). Structure-activity relationship study indicates that introducing substituent in phenyl ring or replacing phenyl ring by pyridine/naphthalene, or decreasing the ring size of lactones (from six to five member) do not increase the cytotoxicity.

Baker's yeast reduction of arylalkyl and arylalkenil γ- and δ-keto acids

γ- and δ-Lactones 5, 6, 13, 14, 15 and 16 were synthesized via baker's yeast reduction of the corresponding keto acids 3, 4 and 9-12. The enantioselectivity of the reduction is strongly dependent on the nature of the keto acid; the δ-lactones ware always obtained in an ee% higher than the γ-lactones and ranging from 70% to 100%.