1197371-65-5Relevant articles and documents
Optimising metabolic stability in lipophilic chemical space: The identification of a metabolically stable pyrazolopyrimidine CRF-1 receptor antagonist
Miller, Duncan C.,Klute, Wolfgang,Calabrese, Andrew,Brown, Alan D.
scheme or table, p. 6144 - 6147 (2010/06/13)
Balancing potency and metabolic stability in a target which favours lipophilic ligands is a considerable challenge. Here we describe two strategies employed to achieve this balance in a series of pyrazolopyrimidine CRF antagonists: moderation of lipophili