119741-57-0Relevant articles and documents
Transition-Metal-Free [3 + 2] Cycloaddition of Nitroolefins and Diazoacetonitrile: A Facile Access to Multisubstituted Cyanopyrazoles
Chen, Zhen,Zhang, Yue,Nie, Jing,Ma, Jun-An
supporting information, p. 2120 - 2124 (2018/04/14)
A transition-metal-free [3 + 2] cycloaddition reaction between nitroolefins and diazoacetonitrile (N2CHCN) is described. This protocol exhibits several merits including simple starting materials, mild reaction conditions, broad substrate scope, good yields, and regioselectivities. The one-pot three-component reaction of nitroolefins with diazoacetonitrile (N2CHCN) and alkyl halides is also developed, thus delivering a series of multisubstituted cyanopyrazoles in good to high yields.
Reaction of 4-Hydroxy-5-oximino-3-thiophenecarboxylates with Hydrazines. Formation of Pyrazolylthiohydroxamic Acids
Robey,Alt,Van Meter
, p. 413 - 428 (2007/10/03)
The reactions of 4-hydroxy-5-oximino-3-thiophenecarboxylates with hydrazine and substituted hydrazines have been investigated. The products of the reactions have been shown to be pyrazole-3- or 5-thiohydroxamic acids rather than the hydrazones previously described by Benary and Silberstrom. Two alternate mechanisms are proposed which account for the regiochemical outcome. The structures of the pyrazole-3- and 5-thiohydroxamic acids and corresponding nitriles have been proven by independent synthesis, comparison to known compounds, and by proton and carbon magnetic resonance and long range HETCOR experiments.
A Novel Regioselective t-Butylation as Applied to the Synthesis of 5-Cyano-1-(1,1-dimethylethyl)-N-methyl-1H-pyrazole-4-carboxamide
Tao, E. V. P.,Aikins, J.,Rizzo, J.,Beck, J. R.,Lynch, M. P.
, p. 1293 - 1294 (2007/10/02)
The title compound was synthesized in a regiocontrolled way from 5-cyano-1H-pyrazole-4-carboxylic acid, ethyl ester (5) with isobutylene, p-toluenesulfonic acid and methylamine.
