119754-16-4

Basic information

• Product Name: p-[Tetrahydropyran-2-yloxy]phenylacetylene
• Synonyms: p-[Tetrahydropyran-2-yloxy]phenylacetylene
• CAS NO: 119754-16-4
• Molecular Formula: C₁₃H₁₄O₂
• Molecular Weight: 0
• Mol File: 119754-16-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: p-[Tetrahydropyran-2-yloxy]phenylacetylene(CAS DataBase Reference)
• NIST Chemistry Reference: p-[Tetrahydropyran-2-yloxy]phenylacetylene(119754-16-4)
• EPA Substance Registry System: p-[Tetrahydropyran-2-yloxy]phenylacetylene(119754-16-4)

Safety Data

• Hazardous Substances Data: 119754-16-4(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 150508-72-8 trimethyl{[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethynyl}silane 
• 119754-13-1 1-[(tetrahydro-2H-pyran-2-yl)oxy]-4-[3-hydroxy-3-methylbut-1-ynyl]benzene 
• 1034-49-7 (bromomethyl)triphenyl phosphonium bromide 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 540-38-5 p-Iodophenol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 36603-49-3 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene 
• 99522-34-6 4-[(tetrahydro-2H-pyran-2-yl)oxy]iodobenzene 

Downstream Products

• 1346558-32-4 4,4'-(benzo[c][1,2,5]thiadiazole-4,7-diylbis(ethyne-2,1-diyl))diphenol 
• 1197188-32-1 9,10-bis-[4-hydroxy phenylethynyl]-anthracene 
• 1415636-40-6 2-(4-((3,3'-bis(heptyloxy)-4'-iodo biphenyl-4-yl)ethynyl)phenoxy)tetrahydro-2Hpyran 

Relevant articles and documents

1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose

The estrogen-related receptor γ (ERRγ) is a potential molecular target for the development of small molecules to stimulate the adipose browning process, which may represent a novel attractive strategy to treat obesity related disorders. The receptor possesses a very small ligand binding cavity and therefore identification of small molecule ERRγ modulators is a considerable challenge. We have successfully designed and synthesized a series of 1-benzyl-4-phenyl-1H-1,2,3-triazoles and demonstrated that they improve the transcriptional functions of ERRγ, potently elevating both the mRNA levels and the protein levels of ERRγ downstream targets. One of the most promising compounds, 4-(1-(4-iso-propylbenzyl)-1H-1,2,3-triazol-4-yl)benzene-1,2-diol (2e) was further shown to directly bind with the ERRγ ligand binding domain (ERRγ-LBD) in an isothermal calorimetric (ITC) assay and to thermally stabilize ERRγ-LBD protein by increasing its melting temperature (Tm) as demonstrated by circular dichroism (CD) spectroscopy. Furthermore, 2e potently stimulates the adipocyte browning process and induces mitochondrial biogenesis both in vitro and in vivo, suggesting the considerable therapeutic potential of this compound for the treatment of obesity and related disorders.

ASCORBATE, VITAMIN K3 AND HYDROXYTOLANS IN THE TREATMENT OF CANCER

The combination of compounds of the hydroxytolan family with ascorbate plus naphthoquinone (Vitamin K3; VK3), or a quinone or semiquinone analogue of VK3, kill tumor cells, inhibit tumor growth and development, and treat cancer in subjects in need thereof.

Liquid crystal dimers derived from naturally occurring chiral moieties: synthesis and characterization

Naturally occurring cholesterol and α-chloroalkanoyl units derived from natural α-amino acids (l-valine, l-leucine, and l-isoleucine) have been utilized to prepare three different series of nonsymmetric liquid crystal dimers. Tolane (diphenylacetylene), w