1198110-06-3

Basic information

• Product Name: 1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(4-fluorophenyl)-[⁽¹¹⁾C]-urea
• CAS NO: 1198110-06-3
• Molecular Weight: 450.418
• Mol File: 1198110-06-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(4-fluorophenyl)-[⁽¹¹⁾C]-urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(4-fluorophenyl)-[⁽¹¹⁾C]-urea(1198110-06-3)
• EPA Substance Registry System: 1-[4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl]-3-(4-fluorophenyl)-[⁽¹¹⁾C]-urea(1198110-06-3)

Safety Data

• Hazardous Substances Data: 1198110-06-3(Hazardous Substances Data)

Upstream product

• 3296-02-4 p-azidofluorobenzene 
• 347161-74-4 4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline 
• 1198110-04-1 4-(4-azido-2-fluoro-phenoxy)-6,7-dimethoxy-quinoline 
• 371-40-4 4-fluoroaniline 

Relevant articles and documents

Rhodium-mediated [11C]Carbonylation: A library of N-phenyl-N′-{4-(4-quinolyloxy)-phenyl}-[11C]-urea derivatives as potential PET angiogenic probes

As part of our ongoing investigation into the imaging of angiogenic processes, a small library of eight vascular endothelial growth factor receptor-2 (VEGFR-2)/platelet-derived growth factor receptor β dual inhibitors based on the N-phenyl-N′-4-(4-quinolyloxy)-phenyl-urea was labelled with 11C (β+, t1/2 = 20.4 min) in the urea carbonyl position via rhodium-mediated carbonylative cross-coupling of an aryl azide and different anilines. The decay-corrected radiochemical yields of the isolated products were in the range of 38-81% calculated from [ 11C]carbon monoxide. Starting with 10.7±0.5 GBq of [ 11C]carbon monoxide, 1-[4-(6,7-dimethoxy-quinolin-4-yloxy)-3-fluoro- phenyl]-3-(4-fluoro-phenyl)-[11C]-urea (2.1 GBq) was isolated after total reaction time of 45 min with a specific activity of 92±4 GBq μmol-1. Copyright