1198179-29-1

Basic information

• Product Name: C₁₉H₂₆N₂O₄
• Synonyms: C₁₉H₂₆N₂O₄
• CAS NO: 1198179-29-1
• Molecular Weight: 346.426
• Mol File: 1198179-29-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₆N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₆N₂O₄(1198179-29-1)
• EPA Substance Registry System: C₁₉H₂₆N₂O₄(1198179-29-1)

Safety Data

• Hazardous Substances Data: 1198179-29-1(Hazardous Substances Data)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 41979-39-9 4-piperidone hydrochloride 

Downstream Products

• 1198179-32-6 (S)-ethyl 2-amino-6-(2-(tert-butoxycarbonylamino)-3-phenylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate 

Relevant articles and documents

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists

A series of 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines were prepared and evaluated as potential allosteric modulators at the A1 adenosine receptor. The structure-activity relationships of the 3- and 6-positions of a series of 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines were explored. Despite finding that 3- and 6-substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines possess the ability to recognize an allosteric site on the agonist-occupied A1AR at relatively high concentrations, the structural modifications we have performed on this scaffold favor the expression of orthosteric antagonist properties over allosteric properties. This research has identified 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as novel class of orthosteric antagonist of the A1AR and highlighted the close relationship between structural elements governing allosteric modulation and orthosteric antagonism of agonist function at the A1AR.