1198213-98-7Relevant articles and documents
Attrition-enhanced deracemization in the synthesis of clopidogrel - A practical application of a new discovery
Van Der Meijden, Maarten W.,Leeman, Michel,Gelens, Edith,Noorduin, Wim L.,Meekes, Hugo,Van Enckevort, Willem J.P.,Kaptein, Bernard,Vlieg, Elias,Kellogg, Richard M.
, p. 1195 - 1198 (2009)
The recently discovered technique of deracemization by means of attrition-induced grinding of a solid conglomerate in contact with a solution wherein racemization occurs has been used with a derivative of 2-chlorophenyl glycine, the key chiral component in the synthesis of Clopidogrel (Plavix). Deracemization of the racemate proceeds to a single enantiomer and in essentially absolute enantiomeric excess. Further conversion of enantiomerically pure material to Clopidogrel was achieved in 88% yield.
