119878-25-0

Basic information

• Product Name: 2-(4-Bromo-phenyl)-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-acetamide
• Synonyms: 2-(4-Bromo-phenyl)-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-acetamide
• CAS NO: 119878-25-0
• Molecular Weight: 365.313
• Mol File: 119878-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-Bromo-phenyl)-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Bromo-phenyl)-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-acetamide(119878-25-0)
• EPA Substance Registry System: 2-(4-Bromo-phenyl)-N-((5S,6R)-1-methyl-1-aza-spiro[4.5]dec-6-yl)-acetamide(119878-25-0)

Safety Data

• Hazardous Substances Data: 119878-25-0(Hazardous Substances Data)

Upstream product

• 119878-14-7 benzyl 10-(methoxyimino)-1-azaspiro<4.5>decane-1-carboxylate 
• 119878-12-5 benzyl 10-oxo-1-azaspiro<4.5>decane-1-carboxylate 
• 119878-11-4 benzyl 10-hydroxy-1-azaspiro<4.5>decane-1-carboxylate 
• 119878-55-6 benzyl N-(3-oxabicyclo<4.1.0>heptan-1-ylpropyl)carbamate 
• 119878-56-7 benzyl N-<3-(1,4-cyclohexadien-1-yl)propyl>carbamate 
• 119907-56-1 benzyl N-<3-(1-cyclohexenyl)propyl>carbamate 
• 21797-84-2 3-(cyclohexa-1,4-dien-1-yl)propan-1-amine 
• 119878-15-8 1-methyl-1-azaspiro<4.5>decan-10-amine 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Relevant articles and documents

Synthesis, Opioid Receptor Binding Profile, and Antinociceptive Activity of 1-Azaspirodecan-10-yl Amides

A series of azaspirodecanyl amides were prepared by a novel cyclization route and examined for opiate receptor binding and antinociceptive activity.Selected tertiary amides in this series showed potent selective μ-receptor binding and antinociceptive activity, in contrast to the less conformationally restricted secondary amides, which showed relatively weak activity.Although structurally similar to the κ-agonist U-50488H (1), these compounds showed virtually no tendency to bind to the κ-receptor.An X-ray crystal structure of compound (21) confirms that the spirocyclic amine does not cause distortion away from the chair conformation of the cyclohexane ring.Either this receptor has very specific requirements for the orientation of the two nitrogens of these compounds or this ring system fills a portion of space more readily tolerated by the μ- and ?-receptors.