119951-96-1

Basic information

• Product Name: Carbamic acid, (3-chloro-4-fluorophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 119951-96-1
• Molecular Formula: C11H13ClFNO2
• Molecular Weight: 245.681
• Mol File: 119951-96-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (3-chloro-4-fluorophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (3-chloro-4-fluorophenyl)-, 1,1-dimethylethyl ester(119951-96-1)
• EPA Substance Registry System: Carbamic acid, (3-chloro-4-fluorophenyl)-, 1,1-dimethylethyl ester(119951-96-1)

Safety Data

• Hazardous Substances Data: 119951-96-1(Hazardous Substances Data)

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 348-51-6 1-chloro-2-fluorobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 36469-95-1 bis-(2-chloro-4-fluoro-phenyl)-diazene 
• 84282-78-0 3-chloro-4-fluorophenyl hydrazine 
• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 1026505-25-8 [3-chloro-4-fluoro-2-(2,2,2-trifluoroethanone)phenyl]carbamic acid tert-butyl ester 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 948913-21-1 C₂₉H₃₂ClFN₆O₄ 
• 77898-24-9 3-chloro-4-fluoro-N-methylaniline 
• 277301-94-7 1-(2-amino-6-chloro-5-fluorophenyl)-2,2,2-trifluoroethanone 

Relevant articles and documents

Catalyst-free chemoselective N-tert-butyloxycarbonylation of amines in water

Catalyst-free N-tert-butyloxycarbonylation of amines in water is reported. The N-t-Boc derivatives were formed chemoselectively without any isocyanate, urea, N,N-di-t-Boc, and O/S-t-Boc as side products. Chiral amines, esters of α-amino acids, and β-amino alcohol afforded optically pure N-t-Boc derivatives. Amino alcohol and 2-aminophenol afforded the N-t-Boc derivative without oxazolidinone formation. Selectivity was observed during competition of aromatic amine vs aliphatic amine, amine vs amino acid ester, amine vs amino alcohol, and primary amine vs secondary amine.

HClO4-SiO2 as a new, highly efficient, inexpensive and reusable catalyst for N-tert-butoxycarbonylation of amines

Perchloric acid adsorbed on silica-gel (HClO4-SiO2) was found to be a new, highly efficient, inexpensive and reusable catalyst for chemoselective N-tert-butoxycarbonylation of amines at room temperature and under solvent-free conditions. The Royal Society of Chemistry 2006.

Mild deprotection of the: N-tert -butyloxycarbonyl (N -Boc) group using oxalyl chloride

We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90percent. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy. This journal is

Teaching Old Compounds New Tricks: DDQ-Photocatalyzed C?H Amination of Arenes with Carbamates, Urea, and N-Heterocycles

The C?H amination of benzene derivatives was achieved using DDQ as photocatalyst and BocNH2 as the amine source under aerobic conditions and visible light irradiation. Electron-deficient and electron-rich benzenes react as substrates with moderate to good product yields. The amine scope of the reaction comprises Boc-amine, carbamates, pyrazoles, sulfonimides and urea. Preliminary mechanistic investigations indicate arene oxidation by the triplet of DDQ to radical cations with different electrophilicity and a charge transfer complex between the amine and DDQ as intermediate of the reaction.