1200-27-7 Usage
Description
1-(4-Fluorophenyl)-2-methyl-2-propylamine is an organic compound with the molecular formula C10H12FN. It is a derivative of 2-methyl-2-propylamine, featuring a fluorophenyl group attached to the nitrogen atom. 1-(4-Fluorophenyl)-2-methyl-2-propylamine is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.
Uses
1. Used in Pharmaceutical Industry:
1-(4-Fluorophenyl)-2-methyl-2-propylamine is used as a reagent for the discovery of benzooxazinones as β2-adrenoceptor agonists. These agonists exhibit bronchodilatory efficacy, which can be beneficial for patients suffering from respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). The compound plays a crucial role in the development of new drugs with improved bronchodilatory properties and longer-lasting effects.
2. Used in Chemical Synthesis:
1-(4-Fluorophenyl)-2-methyl-2-propylamine is also utilized in the synthesis of oxadiazolyl ketones, which are novel and potent inhibitors of dipeptidyl peptidase IV (DPPIV). DPPIV inhibitors have gained significant attention in the pharmaceutical industry due to their potential therapeutic applications in treating type 2 diabetes and other metabolic disorders. The compound serves as a key intermediate in the synthesis of these inhibitors, contributing to the development of more effective treatments for diabetes and related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1200-27-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,0 and 0 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1200-27:
(6*1)+(5*2)+(4*0)+(3*0)+(2*2)+(1*7)=27
27 % 10 = 7
So 1200-27-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H14FN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3
1200-27-7Relevant articles and documents
Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination
Du, Yi-Dan,Chen, Bi-Hong,Shu, Wei
supporting information, p. 9875 - 9880 (2021/03/29)
Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.
POLYMORPHS OF N2-(1, 1' - BIPHENYL - 4 - YLCARBONYL) - N1- [2- (4 - FLUOROPHENYL) -1, 1 - DIMETHYLETHYL]- L - α -GLUTAMINE
-
, (2008/12/05)
Disclosed are novel polymorphic forms of N2-(1, 1'-biphenyl-4-ylcarbonyl)-N1-[2-(4- fluorophenyl)-1, 1-dimethylethyl]-L-α-glutamine, methods of preparing the polymorphic forms, compositions containing the polymorphic forms, and methods of treatment using the polymorphic forms.