120014-33-7

Basic information

• Product Name: Piperidine, 4-(methoxymethylene)-1-(phenylmethyl)-
• CAS NO: 120014-33-7
• Molecular Formula: C14H19NO
• Molecular Weight: 217.311
• Mol File: 120014-33-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Piperidine, 4-(methoxymethylene)-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 4-(methoxymethylene)-1-(phenylmethyl)-(120014-33-7)
• EPA Substance Registry System: Piperidine, 4-(methoxymethylene)-1-(phenylmethyl)-(120014-33-7)

Safety Data

• Hazardous Substances Data: 120014-33-7(Hazardous Substances Data)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 79-37-8 oxalyl dichloride 
• 67686-01-5 1-benzyl-4-piperidinemethanol 

Downstream Products

• 22065-85-6 N-benzyl-4-formylpiperidine 

Relevant articles and documents

Synthesis method of 4-ethynyl-tetrahydropyran or 4-ethynyl piperidine

The invention relates to the technical field of organic synthesis. For solving the problems that a conventional synthesis method of 4-ethynyl-tetrahydropyran and 4-ethynyl piperidine is complex in operation, high in cost and unsuitable for industrial production in the prior art, the invention provides a synthesis method of 4-ethynyl-tetrahydropyran or 4-ethynyl piperidine, wherein the synthesis method comprises the following steps: carrying out Wittig reaction on carbonyl of a compound represented by the formula (I) and phosphorus ylide salt under the action of a strong alkali to generate a compound represented by the formula (II), wherein the reaction temperature is 0-50 DEG C; (2) hydrolyzing the compound represented by the formula (II) to generate a compound represented by the formula (III), wherein the reaction temperature is 20-60 DEG C; (3) carrying out a Corey-Fuchs reaction on the compound represented by the formula (III) to obtain a compound represented by the formula (IV), wherein the reaction temperature is -20 to 40 DEG C; and (4) carrying out a reaction of the compound represented by the formula (IV) with a strong alkali, and carrying out a reaction with a silica reagent to generate a compound represented by the formula (V), wherein the reaction temperature is -70 to 20 DEG C. The method has the advantages of simple and accessible raw materials, low cost, simple synthesis steps and high yield, and is suitable for laboratory small-scale preparation and industrial production.

Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

Compounds of formula (I) : [in which R1 and R2 are each hydrogen or various organic groups, pis 0, 1, 2 or 3, U is -CO- or -CH(OR3)- where R3 is hydrogen or a hydroxy-protecting group, V is an optionally unsaturated aliphatic hydrocarbon group and W is a nitrogen-containing group] are useful in the treatment and prophylaxis of dementia especially of the Alzheimer's type.