120034-05-1

Basic information

• Product Name: METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
• Synonyms: 5-BROMO-3-METHOXYCARBONYL-2(1H)-PYRIDINONE;METHYL 5-BROMO-1,2-DIHYDRO-2-OXO-3-PYRIDINECARBOXYLATE;METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;METHYL 5-BROMO-2-HYDROXYNICOTINATE;METHYL 5-BROMO-2-HYDROXYPYRIDINE-3-CARBOXYLATE;Methyl 5-bromo-2-hydroxynicotinate 97%;methyl5-bromo-2-oxo-1,2-dihydro-3-pyridinecarboxy;5-Bromo-2-hydroxynicotinic acid methyl ester
• CAS NO: 120034-05-1
• Molecular Formula: C₇H₆BrNO₃
• Molecular Weight: 232.03
• Product Categories: blocks;Bromides;Carboxes;Pyridines;Esters
• Mol File: 120034-05-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 181-183°C
• Boiling Point: 346.434 °C at 760 mmHg
• Flash Point: 163.318 °C
• Appearance: /
• Density: 1.738 g/cm³
• Vapor Pressure: 5.76E-05mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Keep Cold
• PKA: 8.01±0.10(Predicted)
• CAS DataBase Reference: METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE(120034-05-1)
• EPA Substance Registry System: METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE(120034-05-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 120034-05-1(Hazardous Substances Data)

Usage

General Description

Methyl 5-Bromo-2-Oxo-1,2-Dihydro-3-Pyridinecarboxylate is a chemical compound with the molecular formula C8H8BrNO3. It is a pyridinecarboxylate ester with a bromo substituent and a carbonyl group. METHYL 5-BROMO-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE is commonly used in the synthesis of pharmaceutical and agrochemical products. It has also been investigated for its potential biological activities, including its antimicrobial and antifungal properties. The chemical structure of Methyl 5-Bromo-2-Oxo-1,2-Dihydro-3-Pyridinecarboxylate makes it a valuable building block in organic synthesis, particularly in the development of new drugs and research into bioactive compounds.

InChI:InChI=1/C7H6BrNO3/c1-12-7(11)5-2-4(8)3-9-6(5)10/h2-3H,1H3,(H,9,10)

Upstream product

• 10128-91-3 methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 10128-91-3 methyl 2-hydroxynicotinate 
• 609-71-2 1,2-dihydro-2-oxonicotinic acid 

Downstream Products

• 78686-79-0 methyl 2-chloro-5-bromonicotinate 
• 1227502-35-3 5-bromo-3-(hydroxymethyl)pyridin-2(1H)-one 

Relevant articles and documents

THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

A thienopyridine derivative compound represented by Formula 1 or pharmaceutically acceptable salts thereof have an excellent inhibitory effect on protein kinase activity, and accordingly, pharmaceutical compositions comprising same can be usefully used for the prevention or treatment of a disease associated with the activity of a protein kinase.

PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS

There are provided inter alia pyrazolyl-substituted pyridone compounds, which exhibit biological activity, e.g., inhibitory action, against serine proteases, including thrombin and various kallikreins. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of serine proteases, including thrombin and various kallikreins.

Process for the preparation of fused pyridine compounds

2-Amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-en-1-yl]pyrido[2,3,-d]pyrimidines and 2-amino-4-hydroxy-6-[2-(4-carboxyphenyl)alk-1-yn-1-yl]pyrido[2,3-d]pyrimidines are prepared through the reaction of a haloaromatic compound and an unsaturated compound in the presence of a palladium catalyst. The products are chemical intermediates for the preparation of antineoplastic agents. A typical embodiment is the reaction of a protected 2-amino-4-hydroxy-6-ethynylpyrido[2,3-d]pyrimidine and an ester of 4-iodobenzoic acid.