1200442-07-4

Basic information

• Product Name: E-6-chloro-3-(3-chloro-benzylidene)-5-fluoro-1,3-dihydro-indol-2-one
• Synonyms: E-6-chloro-3-(3-chloro-benzylidene)-5-fluoro-1,3-dihydro-indol-2-one
• CAS NO: 1200442-07-4
• Molecular Weight: 308.139
• Mol File: 1200442-07-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: E-6-chloro-3-(3-chloro-benzylidene)-5-fluoro-1,3-dihydro-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: E-6-chloro-3-(3-chloro-benzylidene)-5-fluoro-1,3-dihydro-indol-2-one(1200442-07-4)
• EPA Substance Registry System: E-6-chloro-3-(3-chloro-benzylidene)-5-fluoro-1,3-dihydro-indol-2-one(1200442-07-4)

Safety Data

• Hazardous Substances Data: 1200442-07-4(Hazardous Substances Data)

Upstream product

• 100487-74-9 6-Chloro-5-fluoro-1,3-dihydro-2H-indol-2-one 
• 587-04-2 m-Chlorobenzaldehyde 

Relevant articles and documents

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction

We report herein the design of potent and orally active small-molecule inhibitors of the MDM2-p53 interaction. Compound 5 binds to MDM2 with a K i of 0.6 nM, activates p53 at concentrations as low as 40 nM, and potently and selectively inhibits

SPIROINDOLINONE DERIVATIVES

The present invention relates to spiroindolinone derivatives of the formula and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7 and R8, are as herein described.