120061-03-2

Basic information

• Product Name: Phg-MePhe-Thz
• CAS NO: 120061-03-2
• Molecular Weight: 427.524
• Mol File: 120061-03-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phg-MePhe-Thz(CAS DataBase Reference)
• NIST Chemistry Reference: Phg-MePhe-Thz(120061-03-2)
• EPA Substance Registry System: Phg-MePhe-Thz(120061-03-2)

Safety Data

• Hazardous Substances Data: 120061-03-2(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 120061-01-0 Fmoc-Phg-MePhe-Thz-OTmse 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 120060-97-1 Boc-MePhe-Thz-OTmse 
• 37553-65-4 Boc-N-Me-Phe-OH 
• 120060-99-3 MePhe-Thz-OTmse*HCl 
• 102410-65-1 N-(9-Fluorenylmethyloxy)carbonyl-L-phenylglycine 

Relevant articles and documents

SIMULTANEOUS USE OF N-Fmoc AND OTmse PROTECTIVE GROUPS IN THE SYNTHESIS OF PEPTOLYTIC SENSITIVE PEPTIDES

The combined use of Fmoc (fluorenylmethoxycarbonyl) as N-protection and Tmse (trimethylsilylethyl) as O-protection during demanding fragment condensation mediated by Bop-Cl (N,N'-bis(3-oxo-2-oxazolidinyl)phosphinyl chloride) has been explored in the preparation of useful synthons that are sensitive to acidic and even basic hydrolyses.Stepwise deprotection by morfoline (Fmoc-deprotection) followed by F--mediated removal of Tmse results in a very effective peptide synthesis strategy, as exemplified by the preparation of i.a.Phg-MePhe-Thz.Similarly, combinations of N-Boc, O-Tmse peptide esters are also possible that allow the preparation of +H2-MePhe-Thz-OTmse (via Boc-MePhe-Thz-OTmse) without competitive DKP formation.