120075-24-3

Basic information

• Product Name: N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine
• Synonyms: 9-FMOC-D-arginine-(MTR)-OH;(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-(3-(4-methoxy-2,3,6-trimethylphenylsulfonyl)guanidino)pentanoic acid;Fmoc-D-Arginie(Mtr)-OH;N-α-Fmoc-N-ω-4-methoxy-2,3,6-trimeth-yl benzenes;FMoc-D-Arg(Mtr)-OH] N-α-FMoc-N-ω-4-Methoxy-2,3,6-triMeth-yl;Nα-Fmoc-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine≥ 99% (HPLC);Nα-Fmoc-Nω-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine N-(9-Fluorenylmethyloxycarbonyl)-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine;Nalpha-Fmoc-Nomega-(4-methoxy-2,3,6-trimethylphenylsulfonyl)-D-arginine
• CAS NO: 120075-24-3
• Molecular Formula: C31H36N4O7S
• Molecular Weight: 608.71
• Product Categories: Arginine [Arg, R];Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series;Amino Acids
• Mol File: 120075-24-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 807.776 °C at 760 mmHg
• Flash Point: 442.327 °C
• Appearance: /Solid
• Density: 1.361 g/cm³
• Storage Temp.: 2-8°C
• PKA: 3.83±0.21(Predicted)
• CAS DataBase Reference: N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine(120075-24-3)
• EPA Substance Registry System: N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine(120075-24-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 120075-24-3(Hazardous Substances Data)

Usage

Description

N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine, also known as Fmoc-d-arg(mtr)-oh, is a chemical compound used in the field of pharmaceuticals and biochemistry. It is a derivative of the amino acid arginine, with protective groups (Fmoc) and a sulfonyl group attached, which makes it a valuable reagent for various applications.

Uses

Used in Pharmaceutical Research:
N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine is used as a reagent for the determination of the antiangiogenic effect of dual/selective α5β1/αvβ3 integrin antagonists. These integrin antagonists are designed on partially modified retro-inverso cyclotetrapeptide mimetics, which are of interest in the development of new therapeutic strategies for various diseases, including cancer.
Used in Biochemical Research:
In the field of biochemistry, N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine can be used as a building block for the synthesis of peptides and peptidomimetics. The protective Fmoc group allows for selective deprotection and coupling reactions, while the sulfonyl group provides additional functionality for further modifications or conjugations.
Used in Drug Development:
N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine may also be utilized in the development of new drugs targeting integrins, which play a crucial role in various biological processes, such as cell adhesion, migration, and angiogenesis. By understanding the interactions between integrins and their ligands, researchers can design more effective and selective therapeutic agents for the treatment of diseases like cancer and inflammatory disorders.