120081-14-3Relevant articles and documents
Rapid, continuous solution-phase peptide synthesis: Application to peptides of pharmaceutical interest
Carpino, Louis A.,Ghassemi, Shahnaz,Ionescu, Dumitru,Ismail, Mohamed,Sadat-Aalaee, Dean,Truran, George A.,Mansour,Siwruk, Gary A.,Eynon, John S.,Morgan, Barry
, p. 28 - 37 (2003)
The Fmoc/TAEA and Bsmoc/TAEA methods for the rapid, continuous solution synthesis of peptide segments are shown to be applicable to the gram-scale synthesis of short peptides as well as, for the first time, to the synthesis of a relatively long (22-mer) segment, (hPTH 13-34). In the latter case the crude product was of significantly greater purity than a sample obtained via a solid-phase protocol. The Bsmoc methodology was optimized by a new technique involving filtration of the growing partially deprotected peptide at each coupling-deprotection cycle through a short column of silica gel.
