120083-60-5 Usage
General Description
2,3-Pyridinedicarboxylic acid, 5-(trifluoromethyl)-, diethyl ester, also known as TFMDC, is a chemical compound with the molecular formula C13H11F3NO4. It is a diethyl ester of 5-(trifluoromethyl)nicotinic acid and is commonly used in the field of organic synthesis and medicinal chemistry. TFMDC is used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals due to its versatile reactivity and pharmacological properties. It is a colorless to pale yellow liquid with a fruity odor and is typically stored and handled under inert atmosphere or vacuum to prevent degradation. TFMDC is considered to be a hazardous substance and should be handled with appropriate safety precautions.
Check Digit Verification of cas no
The CAS Registry Mumber 120083-60-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,0,8 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 120083-60:
(8*1)+(7*2)+(6*0)+(5*0)+(4*8)+(3*3)+(2*6)+(1*0)=75
75 % 10 = 5
So 120083-60-5 is a valid CAS Registry Number.
120083-60-5Relevant articles and documents
Selective decarboxylation: A facile synthesis of 3-pyridinecarboxylic acid derivative
Wang, Junhua,Wang, Honglin,Ren, Hongmin,Dong, Lihua
, p. 4139 - 4142 (2009)
A convenient synthesis of 5-trifluoromethyl-3-pyridinecarboxylic acid was developed, involving palladium-catalyzed carbonylation, hydrolysis, and decarboxylation. This novel route features inexpensive starting material and easy operations.
Synthetic process development and scale up of palladium-catalyzed alkoxycarbonylation of chloropyridines
Crettaz, Roger,Waser, Jerome,Bessard, Yves
, p. 572 - 574 (2013/09/07)
2,3-Dichloropyridines undergo a mono- or a dicarbonylation in the presence of carbon monoxide, an alcohol, and a palladium catalyst, affording selectively either alkyl 3-chloropyridine-2-carboxylates or dialkyl pyridine-2,3-dicarboxylates in good yields, depending on the reaction conditions. For instance, the process could be scaled up for the monoalkoxycarbonylation of 2,3-dichloro-5-(trifluoromethyl)pyridine, affording in high yield and selectivity the corresponding 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate.
